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Pathogenic Mechanisms of Cancer Causing hMLH1 Mutations

Creator:

O'Donnell, Edmond Francis

Abstract:

DNA mismatch repair (MMR) is an evolutionary conserved process that functions to maintain genomic integrity through the correction of mismatches that have escaped proofreading. Mutations in the MMR gene Mlh1 are associated with approximately 50% of all cases of Lynch syndrome, a hereditary predisposition to colorectal cancer, through varying and...

Resource Type:

Honors College Thesis