This project is about helping protein naturalists understand the protein structure. The database system developed here provides a convenient tool for scientists to explore conformational information in a database of known structures and thereby provide researchers with a deeper and wider view of the empirical data. In this way, it...
Persistent and uncontrolled inflammation is the root cause of various debilitating diseases. Given that interleukin-1 receptor–associated kinase 4 (IRAK4) is a critical modulator of inflammation, inhibition of its activity with selective drug molecules (IRAK4 inhibitors) represents a promising therapeutic strategy for inflammatory disorders. To exploit the full potential of this...
Laser Powder Bed Fusion (LPBF) is a process commonly used to create additively manufactured metal parts. The flexibility and complexity allowed by the LPBF process provides opportunity for significant advancement in multiple industries as parts can be customized in shape and function for specific needs. These benefits can be compounded...
This paper explores the use of sonification, the conversion of data into sound, to convey the significance of SARS-COV-2 and its global impact. It emphasizes sonification as a valuable tool for making complex data accessible, particularly in high school education. Sonification, an interdisciplinary field, leverages the human auditory system's pattern...
This paper addresses the high model complexity and overconfident frame labeling of state-of-the-art (SOTA) action segmenters. Their complexity is typically justified by the need to sequentially refine action segmentation through multiple stages of a deep architecture. However, this multistage refinement does not take into account uncertainty of frame labeling predicted...
Aqueous, two-phase systems (ATPSs) may form upon mixing two solutions of independently water-soluble compounds. Many separation, purification, and extraction processes rely on ATPSs. Predicting the miscibility of solutions can accelerate and reduce the cost of the discovery of new ATPSs for these applications. Whereas previous machine learning approaches to ATPS...
This thesis consists of five chapters: a general introduction, two manuscripts, a collection of published lesson plans, and a general conclusion. The works collected herein are united by the common theme of practical applications in plant breeding. The first manuscript reports a study performed on five malting barley lines grown...
Throughout their lifetime individuals are exposed to complex mixtures of chemicals. The study of chemical mixtures is an internationally recognized research priority, but seemingly complex challenge. To reduce the intricacy of studying mixtures, researchers have identified different prioritization methods based on exposure or the toxicity of chemicals. However, understanding the...
Chloride binding in Portland limestone cements (PLC) can be attributed to the chemical reaction between chloride ions and carboaluminate phases to form Friedel’s salt and the physical interaction between chloride ions and calcium-silicate-hydrates (C-S-H). This thesis examines the chloride binding of mortar samples containing varying amounts of limestone, fly ash,...