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Filtering by: Creator Brown, Laurie L. (Laurie Lee) Has journal sim Behavioural Brain Research

Reducing expression of GluN1OXX subunit splice variants of the NMDA receptor interferes with spatial reference memory

Creator:

Das, Siba R., Jensen, Ross, Kelsay, Rian, Shumaker, Michelle, Bochart, Rachele, Brim, Brenna, Zamzow, Daniel, and Magnusson, Kathy R.

Abstract:

The GluN1 subunit of the NMDA receptor shows age-related changes in its expression pattern, some of which correlate with spatial memory performance in mice. Aged C57BL/6 mice show an age-related increase in mRNA expression of GluN1 subunit splice variants that lack the N terminal splice cassette, GluN1ₒₓₓ (GluN1-a). This increase...

Resource Type:

Article

Full Text:

]. Mice were injected with 5l of either GluN10XX siRNA, control siRNA or vehicle at a depth of 2.7 mm