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Filtering by: Creator Hedstrom, Christopher Has journal sim FEBS Journal

Rationally engineered flavin-dependent oxidase reveals steric control of dioxygen reduction

Creator:

Zafred, Domen, Steiner, Barbara, Teufelberger, Andrea R., Hromic, Altijana, Karplus, P. Andrew, Schofield, Christopher J., Wallner, Silvia, and Macheroux, Peter

Abstract:

The ability of flavoenzymes to reduce dioxygen varies greatly and is controlled by the protein environment that can cause either a rapid (oxidases) or sluggish (dehydrogenases) reaction. Previously, a “gatekeeper” amino acid residue was identified that controls the reactivity to dioxygen in proteins from the vanillyl alcohol oxidase superfamily of...

Resource Type:

Article

Full Text:

Karplus,3 Christopher J. Schofield,4 Silvia Wallner1 and Peter Macheroux1 1 Institute of