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Filtering by: Creator Durkina, Valentina B Has journal sim Frontiers in Aging Neuroscience

Emergence of Microglia Bearing Senescence Markers During Paralysis Progression in a Rat Model of Inherited ALS

Creator:

Trias, Emiliano, Beilby, Pamela R., Kovacs, Mariangeles, Ibarburu, Sofia, Varela, Valentina, Barreto-Nunez, Romina, Bradford, Samuel C., Beckman, Joseph S., and Barbeito, Luis

Abstract:

Age is a recognized risk factor for amyotrophic lateral sclerosis (ALS), a paralytic disease characterized by progressive loss of motor neurons and neuroinflammation. A hallmark of aging is the accumulation of senescent cells. Yet, the pathogenic role of cellular senescence in ALS remains poorly understood. In rats bearing the ALS-linked...

Resource Type:

Article

Full Text:

†, Mariángeles Kovacs1, Sofía Ibarburu1, Valentina Varela1, Romina Barreto-Núñez1, Samuel C. Bradford3, Joseph S