Index Catalog // ScholarsArchive@OSU

Novel Pactamycin Analogs Induce p53 Dependent Cell-Cycle Arrest at S-Phase in Human Head and Neck Squamous Cell Carcinoma (HNSCC) Cells

Creator:: Guha, Gunjan, Lu, Wanli, Li, Shan, Liang, Xiaobo, Kulesz-Martin, Molly F., Mahmud, Taifo, Indra, Arup Kumar, and Ganguli-Indra, Gitali
Abstract:: Pactamycin, although putatively touted as a potent antitumor agent, has never been used as an anticancer drug due to its high cytotoxicity. In this study, we characterized the effects of two novel biosynthetically engineered analogs of pactamycin, de-6MSA-7-demethyl-7- deoxypactamycin (TM-025) and 7-demethyl-7-deoxypactamycin (TM-026), in head and neck squamous cell carcinoma...
Resource Type:: Article
Full Text:: Dependent Cell-Cycle Arrest at S-Phase in Human Head and Neck Squamous Cell Carcinoma (HNSCC) Cells Novel

Coibamide A Induces mTOR-Independent Autophagy and Cell Death in Human Glioblastoma Cells

Creator:: Hau, Andrew M., Greenwood, Jeffrey A., Lohr, Christiane V., Serrill, Jeffrey D., Proteau, Philip J., Ganley, Ian G., McPhail, Kerry L., and Ishmael, Jane E.
Abstract:: Coibamide A is an N-methyl-stabilized depsipeptide that was isolated from a marine cyanobacterium as part of an International Cooperative Biodiversity Groups (ICBG) program based in Panama. Previous testing of coibamide A in the NCI in vitro 60 cancer cell line panel revealed a potent anti-proliferative response and "COMPARE-negative" profile indicative...
Resource Type:: Article
Full Text:: and cells observed using a Nikon Eclipse Ti-S microscope equipped with a Nikon DS-digital CCD camera

Organic Tracers from Asphalt in Propolis Produced by Urban Honey Bees, Apis mellifera Linn.

Creator:: Alqarni, Abdulaziz S., Rushdi, Ahmed I., Owayss, Ayman A., Raweh, Hael S., El-Mubarak, Aarif H., and Simoneit, Bernd R. T.
Abstract:: Propolis is a gummy material produced by honey bees to protect their hives and currently has drawn the attention of researchers due to its broad clinical use. It has been reported, based only on observations, that honey bees also collect other non-vegetation substances such as paint or asphalt/tar to make...
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Full Text:: . D 1 D 2 D 3 D 4 D 5 D 6 D 7 D 9 D 10 D 11 C M ea n S D A sp h al t O ct ad ec en e C

Elemental Markers in Elasmobranchs: Effects of Environmental History and Growth on Vertebral Chemistry

Creator:: Smith, Wade D., Miller, Jessica A., and Heppell, Selina S.
Abstract:: Differences in the chemical composition of calcified skeletal structures (e.g. shells, otoliths) have proven useful for reconstructing the environmental history of many marine species. However, the extent to which ambient environmental conditions can be inferred from the elemental signatures within the vertebrae of elasmobranchs (sharks, skates, rays) has not been...
Resource Type:: Article
Full Text:: s ar e pr es en te d be lo w b ut lo g 1 0 tra ns fo rm at io n w as n ec es sa

Evaluating Temporal Consistency in Marine Biodiversity Hotspots

Creator:: Piacenza, Susan E., Thurman, Lindsey L., Barner, Allison K., Benkwitt, Cassandra E., Boersma, Kate S., Cerny-Chipman, Elizabeth B., Ingeman, Kurt E., Kindinger, Tye L., Lindsley, Amy J., Nelson, Jake, Reimer, Jessica N., Rowe, Jennifer C., Shen, Chenchen, Thompson, Kevin A., and Heppell, Selina S.
Abstract:: With the ongoing crisis of biodiversity loss and limited resources for conservation, the concept of biodiversity hotspots has been useful in determining conservation priority areas. However, there has been limited research into how temporal variability in biodiversity may influence conservation area prioritization. To address this information gap, we present an...
Resource Type:: Article
Full Text:: Biodiversity Hotspots Piacenza, S. E., Thurman, L. L., Barner, A. K., Benkwitt, C. E., Boersma, K. S., Cerny

Patterns and Variation in Benthic Biodiversity in a Large Marine Ecosystem

Creator:: Piacenza, Susan E., Barner, Allison K., Benkwitt, Cassandra E., Boersma, Kate S., Cerny-Chipman, Elizabeth B., Ingeman, Kurt E., Kindinger, Tye L., Lee, Jonathan D., Lindsley, Amy J., Reimer, Jessica N., Rowe, Jennifer C., Shen, Chenchen, Thompson, Kevin A., Thurman, Lindsey L., and Heppell, Selina S.
Abstract:: While there is a persistent inverse relationship between latitude and species diversity across many taxa and ecosystems, deviations from this norm offer an opportunity to understand the conditions that contribute to large-scale diversity patterns. Marine systems, in particular, provide such an opportunity, as marine diversity does not always follow a...
Resource Type:: Article
Full Text:: Biodiversity in a Large Marine Ecosystem Piacenza, S. E., Barner, A. K., Benkwitt, C. E., Boersma, K. S

High-Throughput Sequencing of Arabidopsis microRNAs : Evidence for Frequent Birth and Death of MIRNA Genes

Creator:: Fahlgren, Noah, Howell, Miya D., Kasschau, Kristin D., Sullivan, Christopher M., Cumbie, Jason S., Givan, Scott A., Law, Theresa F., Grant, Sarah R., Dangl, Jeffrey L., and Carrington, James C.
Abstract:: In plants, microRNAs (miRNAs) comprise one of two classes of small RNAs that function primarily as negative regulators at the posttranscriptional level. Several MIRNA genes in the plant kingdom are ancient, with conservation extending between angiosperms and the mosses, whereas many others are more recently evolved. Here, we use deep...
Resource Type:: Article
Full Text:: . Kasschau1, Elisabeth J. Chapman1,2, Christopher M. Sullivan1, Jason S. Cumbie1, Scott A. Givan1, Theresa F

Temporal Genetic Variance and Propagule-Driven Genetic Structure Characterize Naturalized Rainbow Trout (Oncorhynchus mykiss) from a Patagonian Lake Impacted by Trout Farming

Creator:: Benavente, Javiera N., Seeb, Lisa W., Seeb, James E., Arismendi, Ivan, Hernández, Cristián E., Gajardo, Gonzalo, Galleguillos, Ricardo, Cádiz, Maria I., Musleh, Selim S., and Gomez-Uchida, Daniel
Abstract:: Knowledge about the genetic underpinnings of invasions—a theme addressed by invasion genetics as a discipline—is still scarce amid well documented ecological impacts of non-native species on ecosystems of Patagonia in South America. One of the most invasive species in Patagonia’s freshwater systems and elsewhere is rainbow trout (Oncorhynchus mykiss). This...
Resource Type:: Article
Full Text:: I. Cádiz1,6, Selim S. Musleh1,5, Daniel Gomez-Uchida1,6☯* 1 Department of Zoology, Universidad de

Regional Contingencies in the Relationship between Aboveground Biomass and Litter in the World’s Grasslands

Creator:: O’Halloran, Lydia R., Chu, Chengjin, Bakker, Jonathan D., Davies, Kendi F., Du, Guozhen, Firn, Jennifer, Hagenah, Nicole, Hofmockel, Kirsten S., Knops, Johannes M. H., Li, Wei, Melbourne, Brett A., Borer, Elizabeth T., Morgan, John W., Orrock, John L., Prober, Suzanne M., Stevens, Carly J., Seabloom, Eric W., MacDougall, Andrew S., Cleland, Elsa E., McCulley, Rebecca L., Hobbie, Sarah, Harpole, W. Stan, and DeCrappeo, Nicole M.
Abstract:: Based on regional-scale studies, aboveground production and litter decomposition are thought to positively covary, because they are driven by shared biotic and climatic factors. Until now we have been unable to test whether production and decomposition are generally coupled across climatically dissimilar regions, because we lacked replicated data collected within...
Resource Type:: Article
Full Text:: . Borer2, Eric W. Seabloom2, Andrew S. MacDougall3, Elsa E. Cleland4, Rebecca L. McCulley5, Sarah Hobbie2

Historical Biogeography and Diversification of Truffles in the Tuberaceae and Their Newly Identified Southern Hemisphere Sister Lineage

Creator:: Bonito, Gregory, Smith, Matthew E., Nowak, Michael, Healy, Rosanne A., Guevara, Gonzalo, Cazares, Efren, Kinoshita, Akihiko, Nouhra, Eduardo R., Domınguez, Laura S., Tedersoo, Leho, Murat, Claude, Wang, Yun, Arroyo Moreno, Baldomero, Pfister, Donald H., Nara, Kazuhide, Zambonelli, Alessandra, Trappe, James M., and Vilgalys, Rytas
Abstract:: Truffles have evolved from epigeous (aboveground) ancestors in nearly every major lineage of fleshy fungi. Because accelerated rates of morphological evolution accompany the transition to the truffle form, closely related epigeous ancestors remain unknown for most truffle lineages. This is the case for the quintessential truffle genus Tuber, which includes...
Resource Type:: Article
Full Text:: , Akihiko Kinoshita11, Eduardo R. Nouhra5, Laura S. Domı́nguez5, Leho Tedersoo6, Claude Murat7, Yun Wang8

ScholarsArchive@OSU

Novel Pactamycin Analogs Induce p53 Dependent Cell-Cycle Arrest at S-Phase in Human Head and Neck Squamous Cell Carcinoma (HNSCC) Cells

Coibamide A Induces mTOR-Independent Autophagy and Cell Death in Human Glioblastoma Cells

Organic Tracers from Asphalt in Propolis Produced by Urban Honey Bees, Apis mellifera Linn.

Elemental Markers in Elasmobranchs: Effects of Environmental History and Growth on Vertebral Chemistry

Evaluating Temporal Consistency in Marine Biodiversity Hotspots

Patterns and Variation in Benthic Biodiversity in a Large Marine Ecosystem

High-Throughput Sequencing of Arabidopsis microRNAs : Evidence for Frequent Birth and Death of MIRNA Genes

Temporal Genetic Variance and Propagule-Driven Genetic Structure Characterize Naturalized Rainbow Trout (Oncorhynchus mykiss) from a Patagonian Lake Impacted by Trout Farming

Regional Contingencies in the Relationship between Aboveground Biomass and Litter in the World’s Grasslands

Historical Biogeography and Diversification of Truffles in the Tuberaceae and Their Newly Identified Southern Hemisphere Sister Lineage

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