Index Catalog // ScholarsArchive@OSU

Generating Communication -Deficient and -Intensified Neurons to Determine Effects on Multicellular Information Networks

Creator:: Starman, Alia
Abstract:: Multicellular coordination in response to environmental stimuli is essential in biology, and this coordination is often achieved by a division of labor to establish leaders and followers in a cell population. This is called emergent leadership, but how a cell adopts its role and effectively exchanges information with peers is...
Resource Type:: Honors College Thesis
Full Text:: approved:_____________________________________________________ Patrick Chappell Multicellular

The analysis of kisspeptin neuronal exosomes and their effects on neuronal plasticity of downstream gonadotropin-releasing hormone expressing neurons

Creator:: Ewton, Jessica
Abstract:: Gonadotropin-releasing hormone (GnRH) neurons are able to trigger the release of luteinizing hormone and follicle-stimulating hormone which control the maturation of oocytes and ovulation which is vital for reproduction. They are the most downstream neurons that project to the median eminence into the pituitary portal where they release GnRH. Modulation...
Resource Type:: Honors College Thesis
Full Text:: Hormone Expressing Neurons. Abstract approved: a Patrick Chappell Gonadotropin-releasing hormone (GnRH

Circadian Clock Disruption via Exposure to Extended Light at Night (LAN) Alters Epigenetic Expression of CKI Genes in the Murine Mammary Gland

Creator:: Rogers, Zackry L.
Abstract:: Breast cancer is a leading cause of cancer deaths among women, with an estimated 12.4% of American women diagnosed with this tumor type. Evidence suggests that exogenous disruptors can exert epigenetic changes leading to aberrant gene expression, shifting the cellular balance toward oncogenesis. While chemical pollutant exposure is well-studied, light...
Resource Type:: Honors College Thesis
Full Text:: Mammary Gland. Abstract approved:_____________________________________________________ Patrick Chappell

Expression of Gonadotropin-Releasing Hormone Receptor in Kisspeptin Neurons: A Potential Model For Positive Feedback

Creator:: Rayzman, Noa
Abstract:: Estradiol (E2) plays a role in positive and negative feedback mechanisms of the hypothalamic-pituitary-gonadal (HPG) axis in female mammals. These mechanisms are regulated by two different populations of kisspeptin (KP)-producing neurons: anteroventral periventricular (AVPV) neurons, which are stimulated by E2, and arcuate (arc) neurons, which are inhibited by E2. AVPV...
Resource Type:: Honors College Thesis
Full Text:: approved:_____________________________________________________ Patrick Chappell Estradiol (E2) plays a

The Analysis of Kisspeptin Neuronal Exosomes and their Effects in the Periphery at the Level of the Bone

Creator:: James, Teagan
Abstract:: Estrogen (E2) is essential for multiple physiological effects in females, ensuring maximum reproductive fitness and maintaining skeletal homeostasis. E2 has been shown to stimulate cancellous bone formation via activation of estrogen receptor alpha (ERα), an effect widely accepted to be mediated directly at bone. A recent landmark study by Herber...
Resource Type:: Honors College Thesis
Full Text:: :_____________________________________________________ Patrick Chappell Estrogen (E2) is essential for multiple physiological effects in females

Circadian Dysregulation is Associated with Alterations in Tumor Suppressor Activity in Murine Mammary Tissue

Creator:: Aponso, Hiruni M.
Abstract:: Breast cancer is the second most common cancer among women in the US, however, only a small fraction of cases are attributable to heritable genetic mutations; the bulk arises from various behavioral and environmental factors. Loss of functional p53 is observed in over 50% of cases, and its activity relies...
Resource Type:: Honors College Thesis
Full Text:: :_____________________________________________________ Patrick Chappell Breast cancer is the second most common cancer among women in the US

Effect of PFAS Exposure on Reproduction : a Comparative Investigation between Kisspeptin-secreting AVPV and Arcuate Nuclei

Creator:: Jacobs, Dakota
Abstract:: Ovulation requires preovulatory surges of gonadotropin-releasing hormone (GnRH) from preoptic hypothalamic neurons, initiated by elevated ovarian estradiol (E₂). Rising estradiol activates a subset of sexually dimorphic kisspeptin (Kiss-1) neurons in the female, located in the anteroventral periventricular nuclei (AVPV). Conversely, estradiol negative feedback on GnRH secretion is mediated by a...
Resource Type:: Masters Thesis
Full Text:: : ______________________________________________________ Patrick E. Chappell Ovulation requires preovulatory surges of gonadotropin-releasing

Estrogen receptors involved in the differential regulation of hypothalamic kisspeptin expression

Creator:: Alfonzo, Jessica
Abstract:: The hypothalamic neuropeptide kisspeptin (Kiss-1) acts as a central component of the reproductive axis. A critical factor in pubertal progression and normal reproduction, this peptide is an afferent stimulator of gonadotropin-releasing hormone (GnRH), and is responsive to gonadal steroids, integrating steroid hormone signals and modulating GnRH secretion accordingly. Kiss-1 exhibits...
Resource Type:: Undergraduate Thesis
Full Text:: Jacobs2, Patrick Chappell Ph.D3 Bioresource Research, College of Agricultural Science1, Environmental and

Probing Circadian Clock-Steroid Receptor Interactions in GnRH Neurons

Creator:: Grimwood, Victoria J.
Abstract:: Endogenous circadian clock regulation is essential to normal rhythmicity, particularly the timing of hormone release in the brain. In the context of mammalian reproduction, a surge of a specific hormone, gonadotrophin-releasing hormone (GnRH), initiates a surge of luteinizing hormone (LH) from the pituitary gland, which is required for ovulation in...
Resource Type:: Honors College Thesis

Urinary Lipid Biomarkers for Detecting Canine Transitional Cell Carcinoma Pilot Study

Creator:: Pope, George
Abstract:: Canine Transitional Cell Carcinoma (TCC) makes up 2% of all canine cancers and is the most common cancer of the bladder for dogs. Usually diagnosed in its later stages, TCC is difficult to treat, with low survival times. Current diagnosis involves invasive techniques, and mainstream screening tests are often ineffective....
Resource Type:: Undergraduate Thesis and Presentation

ScholarsArchive@OSU

Generating Communication -Deficient and -Intensified Neurons to Determine Effects on Multicellular Information Networks

The analysis of kisspeptin neuronal exosomes and their effects on neuronal plasticity of downstream gonadotropin-releasing hormone expressing neurons

Circadian Clock Disruption via Exposure to Extended Light at Night (LAN) Alters Epigenetic Expression of CKI Genes in the Murine Mammary Gland

Expression of Gonadotropin-Releasing Hormone Receptor in Kisspeptin Neurons: A Potential Model For Positive Feedback

The Analysis of Kisspeptin Neuronal Exosomes and their Effects in the Periphery at the Level of the Bone

Circadian Dysregulation is Associated with Alterations in Tumor Suppressor Activity in Murine Mammary Tissue

Effect of PFAS Exposure on Reproduction : a Comparative Investigation between Kisspeptin-secreting AVPV and Arcuate Nuclei

Estrogen receptors involved in the differential regulation of hypothalamic kisspeptin expression

Probing Circadian Clock-Steroid Receptor Interactions in GnRH Neurons

Urinary Lipid Biomarkers for Detecting Canine Transitional Cell Carcinoma Pilot Study

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