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Genetic Susceptible Locus in NOTCH2 Interacts with Arsenic in Drinking Water on Risk of Type 2 Diabetes

Creator:: Pan, Wen-Chi, Kile, Molly L., Seow, Wei Jie, Lin, Xihong, Quamruzzaman, Quazi, Rahman, Mahmuder, Mahiuddin, Golam, Mostofa, Golam, Lu, Quan, and Christiani, David C.
Abstract:: Abstract: Background: Chronic exposure to arsenic in drinking water is associated with increased risk of type 2 diabetes mellitus (T2DM) but the underlying molecular mechanism remains unclear. Objectives: This study evaluated the interaction between single nucleotide polymorphisms (SNPs) in genes associated with diabetes and arsenic exposure in drinking water on...
Resource Type:: Article
Full Text:: , Xihong Lin3, Quazi Quamruzzaman4, Mahmuder Rahman4, Golam Mahiuddin4, Golam Mostofa4, Quan Lu1,5, David

Arsenic Reduction in Drinking Water and Improvement in Skin Lesions: A Follow-Up Study in Bangladesh

Creator:: Seow, Wei Jie, Pan, Wen-Chi, Kile, Molly L., Baccarelli, Andrea A., Quamruzzaman, Quazi, Rahman, Mahmuder, Mahiuddin, Golam, Mostofa, Golam, Lin, Xihong, and Christiani, David C.
Abstract:: BACKGROUND: Chronic exposure to arsenic is associated with skin lesions. However, it is not known whether reducing arsenic exposure will improve skin lesions. OBJECTIVE: We evaluated the association between reduced arsenic exposures and skin lesion recovery over time. METHODS: A follow-up study of 550 individuals was conducted in 2009-2011 on...
Resource Type:: Article
Full Text:: Quamruzzaman,3 Mahmuder Rahman,3 Golam Mahiuddin,3 Golam Mostofa,3 Xihong Lin,4 and David C. Christiani1

Prenatal Arsenic Exposure and DNA Methylation in Maternal and Umbilical Cord Blood Leukocytes

Creator:: Kile, Molly L., Baccarelli, Andrea, Hoffman, Elaine, Tarantini, Letizia, Quamruzzaman, Quazi, Rahman, Mahmuder, Mahiuddin, Golam, Mostofa, Golam, Hsueh, Yu-Mei, Wright, Robert O., and Christiani, David C.
Abstract:: BACKGROUND: Arsenic is an epigenetic toxicant and could influence fetal developmental programming. OBJECTIVES: We evaluated the association between arsenic exposure and DNA methylation in maternal and umbilical cord leukocytes. METHODS: Drinking-water and urine samples were collected when women were at <= 28 weeks gestation; the samples were analyzed for arsenic...
Resource Type:: Article
Full Text:: Golam Mahiuddin,4 Golam Mostofa,4 Yu-Mei Hsueh,5 Robert O. Wright,2 and David C. Christiani 2 1Oregon

A cross sectional study of anemia and iron deficiency as risk factors for arsenic-induced skin lesions in Bangladeshi women

Creator:: Kile, Molly L., Faraj, Joycelyn M., Ronnenberg, Alayne G., Quamruzzaman, Quazi, Rahman, Mahmudar, Mostofa, Golam, Afroz, Sakila, and Christiani, David C.
Abstract:: Background: In the Ganges Delta, chronic arsenic poisoning is a health concern affecting millions of people who rely on groundwater as their potable water source. The prevalence of anemia is also high in this region, particularly among women. Moreover, arsenic is known to affect heme synthesis and erythrocytes and the...
Resource Type:: Article
Full Text:: , Alayne G. Ronnenberg2, Quazi Quamruzzaman3, Mahmudar Rahman3, Golam Mostofa3, Sakila Afroz3 and David C

Mediating role of arsenic in the relationship between diet and pregnancy outcomes: prospective birth cohort in Bangladesh

Creator:: Lin, Pi-I D., Bromage, Sabri, Mostofa, Md. Golam, Rahman, Mohammad, Allen, Joseph, Oken, Emily, Kile, Molly L., and Christiani, David C.
Abstract:: BackgroundEpidemiological evidence suggests that arsenic (As) exposure during pregnancy may reduce infant birth weight. One significant source of As exposure is diet; thus, As may indirectly affect infant growth by mediating the effect of maternal diet on birth weight (BW). This study evaluated the potential mediating effect of As in...
Resource Type:: Article
Full Text:: : prospective birth cohort in Bangladesh Pi-I D. Lin1,4,6* , Sabri Bromage2, Md. Golam Mostofa3, Mohammad

In Utero Arsenic Exposure and Epigenome-Wide Associations in Placenta, Umbilical Artery and Human Umbilical Vein Endothelial Cells

Creator:: Cardenas, Andres, Houseman, E. Andres, Baccarelli, Andrea A., Quamruzzaman, Quazi, Rahman, Mahmuder, Mostofa, Golam, Wright, Robert O., Christiani, David C., and Kile, Molly L.
Abstract:: Exposure to arsenic early in life has been associated with increased risk of several chronic diseases and is believed to alter epigenetic programming in utero. In the present study, we evaluate the epigenome-wide association of arsenic exposure in utero and DNA methylation in placenta (n = 37), umbilical artery (n...
Resource Type:: Article
Full Text:: Cardenas1, E. Andres Houseman1, Andrea A. Baccarelli2, Quazi 3 Quamruzzaman3, Mahmuder Rahman3, Golam

Estimating effects of arsenic exposure during pregnancy on perinatal outcomes in a Bangladeshi cohort

Creator:: Kile, Molly L., Cardenas, Andres, Rodrigues, Ema, Mazumdar, Maitreyi, Dobson, Christine, Golam, Mostofa, Quamruzzaman, Quazi, Rahman, Mahmudar, and Christiani, David C.
Abstract:: BACKGROUND: The relationship between arsenic and birth weight is not well understood. OBJECTIVE: To evaluate the causal relationship between prenatal arsenic exposure and birth weight considering the potential mediation effects of gestational age (GA) and maternal weight gain (MWG) during pregnancy using structural equation models (SEMs). METHODS: A prospectively enrolled...
Resource Type:: Article
Full Text:: ., Rodrigues, E., Mazumdar, M., Dobson, C., Golam, M., ... & Christiani, D. C. (2015). Estimating effects of

Neurodevelopmental outcomes among 2-to 3-year-old children in Bangladesh with elevated blood lead and exposure to arsenic and manganese in drinking water

Creator:: Rodrigues, Ema G., Bellinger, David C., Valeri, Linda, Hasan, Md Omar Sharif Ibne, Quamruzzaman, Quazi, Golam, Mostofa, Kile, Molly L., Christiani, David C., Wright, Robert O., and Mazumdar, Maitreyi
Abstract:: Background: The people of Bangladesh are currently exposed to high concentrations of arsenic and manganese in drinking water, as well as elevated lead in many regions. The objective of this study was to investigate associations between environmental exposure to these contaminants and neurodevelopmental outcomes among Bangladeshi children. Methods: We evaluated...
Resource Type:: Article

A prospective cohort study of the association between drinking water arsenic exposure and self-reported maternal health symptoms during pregnancy in Bangladesh

Creator:: Kile, Molly L., Rodrigues, Ema G., Mazumdar, Maitreyi, Dobson, Christine B., Diao, Nancy, Golam, Mostofa, Quamruzzaman, Quazi, Rahman, Mahmudar, and Christiani, David C.
Abstract:: BACKGROUND: Arsenic, a common groundwater pollutant, is associated with adverse reproductive health but few studies have examined its effect on maternal health. METHODS: A prospective cohort was recruited in Bangladesh from 2008–2011 (N = 1,458). At enrollment (<16 weeks gestational age [WGA]), arsenic was measured in personal drinking water using...
Resource Type:: Article

Prenatal and Early-life Metals Exposure and Immune Function in Children

Creator:: Welch, Barrett M.
Abstract:: Immune system development during prenatal and early-life periods are essential for healthy development. Environmental and nutritional factors during these periods have strong influences on immune development and can have impacts on disease susceptibility for an individual throughout adulthood. Globally, hundreds of millions of people experience elevated environmental exposure to arsenic,...
Resource Type:: Dissertation
Full Text:: . Dr. Quazi Quamruzzaman, Mostofa Golam, Sakila Afroz Joya, Dr. Omar Sharif Ibn Hasan, and Dr

ScholarsArchive@OSU

Genetic Susceptible Locus in NOTCH2 Interacts with Arsenic in Drinking Water on Risk of Type 2 Diabetes

Arsenic Reduction in Drinking Water and Improvement in Skin Lesions: A Follow-Up Study in Bangladesh

Prenatal Arsenic Exposure and DNA Methylation in Maternal and Umbilical Cord Blood Leukocytes

A cross sectional study of anemia and iron deficiency as risk factors for arsenic-induced skin lesions in Bangladeshi women

Mediating role of arsenic in the relationship between diet and pregnancy outcomes: prospective birth cohort in Bangladesh

In Utero Arsenic Exposure and Epigenome-Wide Associations in Placenta, Umbilical Artery and Human Umbilical Vein Endothelial Cells

Estimating effects of arsenic exposure during pregnancy on perinatal outcomes in a Bangladeshi cohort

Neurodevelopmental outcomes among 2-to 3-year-old children in Bangladesh with elevated blood lead and exposure to arsenic and manganese in drinking water

A prospective cohort study of the association between drinking water arsenic exposure and self-reported maternal health symptoms during pregnancy in Bangladesh

Prenatal and Early-life Metals Exposure and Immune Function in Children

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