Throughput-oriented processors, such as graphics processing units (GPUs), have been increasingly used to accelerate general purpose computing, including machine learning models that are being utilized in numerous disciplines. Thousands of concurrently running threads in a GPU demand a highly efficient memory subsystem for data supply in GPUs. In this dissertation,...
RNA-Sequencing (RNA-Seq) has rapidly become the de facto technique in transcriptome studies. However, established statistical methods for analyzing experimental and observational microarray studies need to be revised or completely re-invented to accommodate RNA-Seq data's unique characteristics. In this dissertation, we focus on statistical analyses performed at two particular stages in...
Antisense oligonucleotide (AO)-mediated exon-skipping therapeutics shows great promise in correcting frame-disrupting mutations in the DMD gene for Duchenne muscular dystrophy. However, insufficient systemic delivery limits clinical adoption. Previously, we showed that a glucose/fructose mixture augmented AO delivery to muscle in mdx mice. Here, we evaluated if fructose alone could enhance...
Diatomaceous soils are a geological material whose engineering properties do not readily conform to the widely accepted and used mechanical and behavioral frameworks. This ambiguity results in design difficulties and geotechnical failures which can be costly. Diatomaceous soils have diatoms in their matrix. Diatoms are unicellular algae with an inert...
The Discrete Cosine Transform is used in many image and video compression
standards. Many methods have been developed for efficiently computing the Discrete
Cosine Transform including flowgraph algorithms, distributed arithmetic and
two-dimensional decompositions.
A new architecture based on distributed arithmetic is presented for computing
the Discrete Cosine Transform and it's...
The Laplace-Beltrami operator of a smooth Riemannian manifold is determined by the Riemannian metric. Conversely, the heat kernel constructed from the eigenvalues and eigenfunctions of the Laplace-Beltrami operator determines the Riemannian metric. This work proves the analogy on Euclidean polyhedral surfaces (triangle meshes), that the discrete heat kernel and the...
In a wireless sensor network, sensor nodes are deployed in an ad hoc fashion and they deliver data packets using multihop transmission. However, transmission failures occur frequently in the multihop transmission over wireless media. Thus, a loss recovery mechanism is required to provide end-to-end reliability. In addition, because the sensor...
Various natural language processing (NLP) tasks necessitate deep models that are fast, efficient, and small based on their ultimate application at the edge or elsewhere. While significant investigation has furthered the efficiency and reduced the size of these models, reducing their downstream latency without significant trade-offs remains a difficult task....
This work presents a new energy saving technique for modern digital designs. We propose Time Interleaved Multi-Rail (TIMR) - a method for providing two dynamic supply rails to a circuit. This technique uses the first supply rail to mask the transition delay while changing the voltage of the second rail....