Index Catalog // ScholarsArchive@OSU

Growth pathways in feline oral squamous cell carcinoma

Creator:: Harris, Krystal, L.
Abstract:: Background Bcl11b, previously CTIP2, is a zinc finger nuclear transcription factor involved in the development of keratinocytes, teeth, T lymphocytes, and nervous tissue. Expression of Bcl11b has been reported in human head and neck squamous cell carcinoma (HNSCC) and increased expression correlates with poorly differentiated tumors. This study aimed to...
Resource Type:: Masters Thesis
Full Text:: approved: _____________________________________________________________________ Stuart C. Helfand

Expression of prolactin in feline mammary adenomas and adenocarcinomas

Creator:: Trummel, Danielle K.
Abstract:: Mammary tumors are the third most common tumor in cats after cutaneous neoplasia and lymphosarcoma. More than 80% of feline mammary tumors are adenocarcinomas, which are similar to human mammary adenocarcinomas in their biologic behavior and histologic characteristics. Despite treatment with radical mastectomy, feline mammary adenocarcinoma is associated with a...
Resource Type:: Undergraduate Thesis and Presentation
Full Text:: ________________________________________________________________________ Secondary Mentor: Dr. Stuart Helfand Date

The role of keratinocytic RXRα in regulating melanocyte homeostasis and carcinogen induced melanomagenesis, The role of keratinocytic RXR[alpha] in regulating melanocyte homeostasis and carcinogen induced melanomagenesis

Creator:: Hyter, Stephen D.
Abstract:: Cutaneous melanoma remains the deadliest form of skin cancer, with a diagnosis of metastasis indicating a median survival rate of less than a year. Solar ultraviolet (UV) radiation, especially childhood sun exposure, is an important etiological risk factor of melanoma. Previous studies determined that mice selectively lacking the nuclear hormone...
Resource Type:: Dissertation
Full Text:: ). PPARs are transcriptionally regulated by AP-1, C/EBP family members and p63, the master regulator of

Dasatinib Modulates Invasive and Migratory Properties of Canine Osteosarcoma and has Therapeutic Potential in Affected Dogs

Creator:: Marley, Kevin, Gullaba, Justine, Seguin, Bernard, Gelberg, Howard B., and Helfand, Stuart C.
Abstract:: BACKGROUND: This investigation sought to elucidate the relationship between hepatocyte growth factor (HGF)–induced metastatic behavior and the tyrosine kinase inhibitors (TKIs) crizotinib and dasatinib in canine osteosarcoma (OS). Preliminary evidence of an apparent clinical benefit from adjuvant therapy with dasatinib in four dogs is described. METHODS: The inhibitors were assessed...
Resource Type:: Article
Full Text:: , Bernard Seguin2, Howard B. Gelberg and Stuart C. Helfand Department of Clinical Sciences Oregon State

The effects of taurolidine alone and in combination with doxorubicin or carboplatin in canine osteosarcoma in vitro

Creator:: Marley, Kevin, Helfand, Stuart C., Edris, Wade A., Mata, John E., Gitelman, Alix I., Medlock, Jan, and Seguin, Bernard
Abstract:: Background: Osteosarcoma (OS) affects over 8000 dogs/year in the United States. The disease usually arises in the appendicular skeleton and metastasizes to the lung. Dogs with localized appendicular disease benefit from limb amputation and chemotherapy but most die within 6–12 months despite these treatments. Taurolidine, a derivative of taurine, has...
Resource Type:: Article
Full Text:: osteosarcoma in vitro Kevin Marley1, Stuart C Helfand1, Wade A Edris1,4, John E Mata2, Alix I Gitelman3, Jan

Antiproliferative effects of masitinib and imatinib against canine oral fibrosarcoma in vitro

Creator:: Milovancev, Milan, Helfand, Stuart C., Marley, Kevin, Goodall, Cheri P., Löhr, Christiane V., and Bracha, Shay
Abstract:: Background: Canine oral fibrosarcoma (COF) is one of the most common oral tumors in dogs and carries a guarded prognosis due to a lack of effective systemic therapeutic options. Mastinib and imatinib are two commonly used tyrosine kinase inhibitors (TKIs) in veterinary oncology but their potential efficacy against COF is...
Resource Type:: Article
Full Text:: *, Stuart C. Helfand1, Kevin Marley1, Cheri P. Goodall1, Christiane V. Löhr2 and Shay Bracha1 Abstract

Pharmacokinetic study and evaluation of the safety of taurolidine for dogs with osteosarcoma

Creator:: Marley, Kevin, Helfand, Stuart C., Simpson, Jennifer, Mata, John E., Tracewell, William G., Brownlee, Lisa, Bracha, Shay, and Séguin, Bernard
Abstract:: Background: Osteosarcoma in dogs and humans share many similarities and the dog has been described as an excellent model to study this disease. The median survival in dogs has not improved in the last 25 years. Taurolidine has been shown to be cytotoxic to canine and human osteosarcoma in vitro....
Resource Type:: Article
Full Text:: the safety of taurolidine for dogs with osteosarcoma Kevin Marley1, Stuart C Helfand1, Jennifer

Isolation and partial characterization of temperature sensitive division mutants of Chlamydomonas reinhardtii

Creator:: Wolff, Darold Melvin, 1940-
Abstract:: The primary objective of this study was to develop methods for the selection of temperature sensitive division (TSD) mutants of Chlamydomonas reinhardtii. Such methods were developed and four temperature sensitive (TS) mutants were isolated and partially characterized. Wild type (WT) cells of the plus mating type were synchronized by a...
Resource Type:: Dissertation
Full Text:: MUTANTS OF CHLAMYDOMONAS REINHARDTII Abstract approved: Redacted for Privacy D. 'Stuart Nacht The

Vet Gazette ; October 15, 2008

Creator:: Oregon State University. College of Veterinary Medicine
Abstract:: Bi-weekly newsletter of the Oregon State University College of Veterinary Medicine.
Resource Type:: Other
Full Text:: awarded $200,000 grant to study hemangiosarcoma in canines Dr. Stuart Helfand and his colleague Dr

Dissonance of the Self: Applying the Philosophy of Patañjali’s Yogasūtra to the Effects of Prolonged Engagement in Virtual Synchronous Platforms

Creator:: Darshana, Jocelyn D.
Abstract:: This thesis analyzes contributing factors to Zoom Fatigue and the issues surrounding “attentional dissonance,” or a feeling of tension or rupture between actual and virtual self-perception. The research examines current literature on Zoom Fatigue, and uses the sociological theory of Dramaturgical Analysis, developed by Erving Goffman, to further assess the...
Resource Type:: Masters Thesis
Full Text:: : _______________________________________________________________ Stuart R. Sarbacker This thesis analyzes contributing factors to Zoom Fatigue and

ScholarsArchive@OSU

Growth pathways in feline oral squamous cell carcinoma

Expression of prolactin in feline mammary adenomas and adenocarcinomas

The role of keratinocytic RXRα in regulating melanocyte homeostasis and carcinogen induced melanomagenesis, The role of keratinocytic RXR[alpha] in regulating melanocyte homeostasis and carcinogen induced melanomagenesis

Dasatinib Modulates Invasive and Migratory Properties of Canine Osteosarcoma and has Therapeutic Potential in Affected Dogs

The effects of taurolidine alone and in combination with doxorubicin or carboplatin in canine osteosarcoma in vitro

Antiproliferative effects of masitinib and imatinib against canine oral fibrosarcoma in vitro

Pharmacokinetic study and evaluation of the safety of taurolidine for dogs with osteosarcoma

Isolation and partial characterization of temperature sensitive division mutants of Chlamydomonas reinhardtii

Vet Gazette ; October 15, 2008

Dissonance of the Self: Applying the Philosophy of Patañjali’s Yogasūtra to the Effects of Prolonged Engagement in Virtual Synchronous Platforms

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