Index Catalog // ScholarsArchive@OSU

Acute bioactivation and hepatotoxicity of ketoconazole in rat and the determinant presence of flavin-containing monooxygenase (FMO) isoforms in human duodenum, jejunum, ileum, and colon microsomes and Caco-2 cell line

Creator:: Buckholz, Cheryl J.
Abstract:: Two specific goals were addressed for this dissertation. First to investigate and identify the mechanistic profile of ketoconazole (KT)-induced hepatotoxicity by utilizing in vivo and in vitro approaches determining the mechanism of action for the hepatotoxicity incurred. To date, there has not been a mechanistic determination of the hepatotoxicity associated...
Resource Type:: Dissertation
Full Text:: either phase I or phase II enzymes could have an effect on the efficacy or toxicity of therapeutic drugs

The effects of atrazine on growth of flax (Linum usitatissimum L.) plants and on yield, chemical composition and germination of flax seeds

Creator:: Locatelli, Eduardo Atilio
Abstract:: Reports of previous research indicated a stimulatory effect of triazine herbicides on growth, yield and protein content of plants and seeds of various species. Studies were conducted in the greenhouse, laboratory and field to investigate the effects of atrazine (2-chloro-4-ethylamino-6-a sopropylarnino- s-triazine) on growth, yield, seed composition, and seed germination...
Resource Type:: Masters Thesis
Full Text:: Reports of previous research indicated a stimulatory effect of triazine herbicides on growth, yield and

Chlordecone impaired biliary excretion : in vivo and in vitro correlates

Creator:: Rochelle, Lori G.
Resource Type:: Dissertation
Full Text:: Corvallis, Oregon 97331-3803 12 Abstract The effect of in vitro chlordecone (CD) treatment on hepatic

Individual and demographic responses of the gray-tailed Vole (Microtus canicaudus) to an endocrine disruptor

Creator:: Caslin, Tracie M.
Abstract:: In an experimental field study, populations of gray-tailed voles (Microtus canicaudus) were exposed to a commercial formulation of vinclozolin, a fungicide effective for disease control on ornamental plants, turf grasses, and fruits and vegetables. Vinclozolin has been shown in laboratory experiments to behave as an androgen antagonist, impairing the reproductive...
Resource Type:: Masters Thesis
Full Text:: with one application of Curalan® fungicide, Vinclozolin had only a slight effect on the reproductive

Developmental axial skeletal deformities : baseline study with a zebrafish model

Creator:: Harden, Jon M.
Abstract:: The aim of this study was to assess sensitivity of early life stage zebrafish to cadmium (Cd). Embryos and larva were exposed to Cd before the formation of skeletal elements. Exposure times were selected to determine whether Cd perturbed developmental processes that lead to skeletal deformities, and to characterize the...
Resource Type:: Masters Thesis
Full Text:: . There was no effect of Cd on incidence of any type of skeletal deformity at 4Odpf(P>O.05 and p>O.O5

Absorption and metabolism of selenite by perfused small intestine, and hepatocytes from rats

Creator:: Park, Yeong-Chul
Resource Type:: Dissertation
Full Text:: selenite on its absorption 25 Time course of sodium selenite transport 26 Chemical forms in the vascular

Oxidative stress and carcinogenesis in trout

Creator:: Kelly, Jack D.
Resource Type:: Dissertation
Full Text:: approved:4 David E. Williams The inhibitory effect of antioxidants in the multi-stage chemical

Chemodetection of threatening chemical stimuli by juvenile coho salmon (Oncorhynchus kisutch)

Creator:: Stone, Steven L.
Resource Type:: Masters Thesis
Full Text:: discriminate between stressed and unstressed conspecifics solely on the basis of chemical stimuli. In a two

Soil pH and calcium effects on nodulation of nursery grown red alder

Creator:: Crannell, Wanda K.
Resource Type:: Masters Thesis
Full Text:: ., 1985). The effect of increased bases in the soil surface layers on subsequent nodulation is often

Vitellogenesis : a biomarker for estrogenic and antiestrogenic effects of organochlorines in rainbow trout

Creator:: Donohoe, Regina M.
Abstract:: Persistent organochlorines (OCs) bioaccumulate in aquatic biota and potentially impair reproduction via endocrine disruption. The present research evaluated estrogenic effects of the OCs, chlordecone (CD) and o,p'-DDT/DDE, and the antiestrogenicity of 3,4,5,3',4',5'-hexachlorobiphenyl (345-HCB) in juvenile rainbow trout, utilizing vitellogenesis as a biomarker. Vitellogenesis, estrogen regulated hepatic production of the yolk...
Resource Type:: Dissertation
Full Text:: synthesis and lipid metabolism (Cyr et al., 1988) but no evidence of a direct effect on Vg synthesis is

ScholarsArchive@OSU

Acute bioactivation and hepatotoxicity of ketoconazole in rat and the determinant presence of flavin-containing monooxygenase (FMO) isoforms in human duodenum, jejunum, ileum, and colon microsomes and Caco-2 cell line

The effects of atrazine on growth of flax (Linum usitatissimum L.) plants and on yield, chemical composition and germination of flax seeds

Chlordecone impaired biliary excretion : in vivo and in vitro correlates

Individual and demographic responses of the gray-tailed Vole (Microtus canicaudus) to an endocrine disruptor

Developmental axial skeletal deformities : baseline study with a zebrafish model

Absorption and metabolism of selenite by perfused small intestine, and hepatocytes from rats

Oxidative stress and carcinogenesis in trout

Chemodetection of threatening chemical stimuli by juvenile coho salmon (Oncorhynchus kisutch)

Soil pH and calcium effects on nodulation of nursery grown red alder

Vitellogenesis : a biomarker for estrogenic and antiestrogenic effects of organochlorines in rainbow trout

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