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Filtering by: Creator Wong, Carmen P. Remove constraint Creator: Wong, Carmen P. Language English [eng] Remove constraint Language: English [eng]

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  • Photochemistry of 6-alkenyl-2-cyclohexenones : synthetic studies towards precursors of ryanodol

    Creator:
    Wang, Bingbing
    Abstract:
    Regiochemistry of intramolecular [2+2] photocycloadditions of oxygenated 6-alkenyl-3-alkoxy-2-cyclohexenones is studied. Application of this methodology to construct a key intermediate [3.3.2] bicyclic skeleton of ryanodol is described as well. Irradiation of (3-butenyl)compounds 3, 11, 14 and of (4-pentenyl)compound 6 afforded exclusively the linear photoadducts 4, 12, 15 and 7 respectively. Irradiation...
    Resource Type:
    Masters Thesis
    Full Text:
    Redacted for Privacy Redacted for Privacy Acknowledgments To my major advisor Dr. Carmen Somoza for

  • Differences in expression of COVID-19 related inflammatory genes in non-human primates with varying alcohol consumption

    Creator:
    Co, Amber
    Abstract:
    Severe cases of COVID-19 have been associated with cytokine storms, leading to widespread inflammation, tissue damage, and organ failure. Pro-inflammatory cytokines have also been shown to play a role in liver diseases, including alcoholic liver disease. To investigate alcohol consumption as a risk factor for SARS-CoV-2 infections and COVID-19 severity,...
    Resource Type:
    Honors College Thesis
    Full Text:
    Sciences _____________________________________________________________________ Carmen Wong

  • The Effect of Zinc Status and Age on Liver Health in Mice

    Creator:
    Braun, Kendra N.
    Abstract:
    Age-related diseases have been associated with chronic inflammation and impaired immune response, one of the hallmarks of aging. Aging individuals also have a higher susceptibility to zinc deficiency. The effects of zinc deficiency share many commonalities with the effects of aging on the immune system and zinc deficiency may be...
    Resource Type:
    Honors College Thesis
    Full Text:
    _____________________________________________________________________ Carmen P. Wong, Committee Member, representing Biological and Population Health Science

  • Investigating the Interplay of Age, Zinc Status, and the Gut Microbiome on Gut Health

    Creator:
    Vasudevan, Anusha
    Abstract:
    Zinc is an important micronutrient involved in many cellular processes, including those part of immune function; however, about 15% of the US population is at risk for marginal zinc deficiency. This can lead to immune system complications including the generation of inflammatory cytokines. Aging is another factor that worsens the...
    Resource Type:
    Honors College Thesis
    Full Text:
    _____________________________________________________________________ Carmen Wong, Committee Member, representing Nutrition and Public Health

  • Effects of low zinc status and arsenic exposure in mice

    Creator:
    Chase, Tyler, Wong, Carmen P., and Ho, Emily
    Abstract:
    During fall term of 2015 and winter and spring term of 2016 I assisted in research within Dr. Emily Ho’s lab. The project that I assisted in looked at the effects of low zinc status and arsenic exposure in mice. Zinc is an essential micronutrient involved in numerous cellular processes...
    Resource Type:
    Poster
    Full Text:
    Effects of low zinc status and arsenic exposure in mice Tyler T. Chase1, Carmen P. Wong1,2, Emily Ho1,2

  • Aging in place : a contemporary social phenomenon

    Creator:
    Lee, Megan
    Abstract:
    Most aging individuals prefer to remain in a self-determined home environment, and generally aging adults want to remain in the same home or same community. The benefits of remaining in a self-determined private home environment while aging have been established. Because individuals present a diversity of needs, it takes interdisciplinary...
    Resource Type:
    Dissertation
    Full Text:
    Place: A Contemporary Social Phenomenon Abstract approved: Carmen D. Steggell

  • Synthetic studies toward a total synthesis of paeoniflorigenin

    Creator:
    Hong, Zhenqiu
    Abstract:
    A new approach towards a total synthesis of paeoniflorigenin is discussed. The approach involves the application of regio- and stereoselective [2+2] photocycloaddition for the preparation of a key intermediate, cyclobutanone 86, and model studies on diiodosamarium (Sm12) mediated pinacol coupling of a diketone. Intermolecular [2+2] photocycloaddition of a,13unsaturated lactam 33...
    Resource Type:
    Masters Thesis
    Full Text:
    . Abstract approved: Carmen Somoza A new approach towards a total synthesis of paeoniflorigenin is

  • Increased inflammatory response in aged mice is associated with age-related zinc deficiency and zinc transporter dysregulation

    Creator:
    Wong, Carmen P., Mangusson, Kathy R., and Ho, Emily
    Abstract:
    Aging is a complex process associated with physiological changes in numerous organ systems. In particular, aging of the immune system is characterized by progressive dysregulation of immune responses, resulting in increased susceptibility to infectious diseases, impaired vaccination efficacy, as well as systemic low grade chronic inflammation. Increasing evidence suggest that...
    Resource Type:
    Article
    Full Text:
    associated with age-related zinc deficiency and zinc transporter dysregulation Carmen P. Wong1, Kathy R

  • Docosahexaenoic acid attenuates Western diet-induced hepatic fibrosis in Ldlr(-/-) mice by targeting the TGFβ-Smad3 pathway

    Creator:
    Lytle, Kelli A., Depner, Christopher M., Wong, Carmen P., and Jump, Donald B.
    Abstract:
    DHA (22:6,ω3), but not EPA (20:5,ω3), attenuates Western diet (WD)-induced hepatic fibrosis in a Ldlr[superscript −/−] mouse model of nonalcoholic steatohepatitis. We examined the molecular basis for the differential effect of dietary EPA and DHA on WD-induced hepatic fibrosis. DHA was more effective than EPA at preventing WD-induced effects on...
    Resource Type:
    Article

  • Homeownership : still the American Dream? Perceptions of homeownership in the post crisis era

    Creator:
    Micek, Thomas P.
    Abstract:
    "The American Dream" is an expression familiar to all Americans and the realization of the American Dream is tied closely to homeownership (Clinton, 1995). The recent financial crisis, with the housing and financial markets at levels not seen since the Great Depression, has resulted in widespread unemployment, continually dropping home...
    Resource Type:
    Masters Thesis
    Full Text:
    Abstract approved: Carmen D. Steggell “The American Dream” is an expression familiar to all