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  • Surface Characterization of Engineered Biomaterials

    Creator:
    Faase, Ryan A.
    Abstract:
    The work presented in this dissertation highlights the various techniques available to characterize the increasingly complex surfaces of engineered biomaterials. The methods used range from the simple measurement of a contact angle with a smartphone to a complex synchrotron technique like near edge x-ray absorption fine structure (NEXAFS) spectroscopy to...
    Resource Type:
    Dissertation
    Full Text:
    : ______________________________________________________ Joe E. Baio Abstract: The work presented in this dissertation highlights the various

  • Bioactive and Biocompatible Coatings for Endotoxin Capture in Treatment of Sepsis

    Creator:
    Su, Jonathan
    Abstract:
    Sepsis is a blood infection caused by circulating pathogens and cell wall fragments that affects over 1 million patients per year in the United States. When bacterial cell membranes are lysed by antibiotics, cell wall fragments containing lipopolysaccharides (LPS) are released. As a result, the capture of LPS is critical...
    Resource Type:
    Honors College Thesis
    Full Text:
    _____________________________________________________________________ Joe Baio, Committee Member, representing Chemical, Biological, and Environmental Engineering

  • Conformational Consequences: Calcium Regulates the Association Between Dysferlin C2A & PI(4,5)P2

    Creator:
    Otto, Shauna C.
    Abstract:
    Dysferlin is a ∼230 kDa terminally anchored membrane protein that is ubiquitously expressed, but is particularly enriched in skeletal and cardiac muscle tissue. Mutations covering the length of the protein have been linked to muscle wasting diseases including limb-girdle muscular dystrophy and Myoshi myopathy. Dysferlin has been shown to play...
    Resource Type:
    Dissertation
    Full Text:
    roadblocks. I also thank my graduate committee, Dr. Elisar Barbar, Dr. Patrick Reardon, Dr. Joe Baio, and Dr

  • Exploring the Limits of Ligation Rate and Specificity in Protein Immobilization Using the Genetically Encoded Tetrazine Ligation

    Creator:
    Bednar, Riley M.
    Abstract:
    Immobilized proteins are integral components of a number of important technologies, including the principal component of many biosensors, as functional coatings in various implants, as catalysts is industrial biosynthesis, and as the building blocks of next-generation nanotechnologies. Despite their ubiquity, relatively little is known about the processes that shape immobilized...
    Resource Type:
    Dissertation

  • Characterizing the Functional Properties of Otoferlin, Essential for Neurotransmission in Inner Hair Cells of the Cochlea

    Creator:
    Narayanappa, Murugesh
    Abstract:
    Hearing loss is one of the most common defect, affecting 360 million people worldwide due to several factors including congenital, present at or soon after birth or acquired with age. Congenital hearing loss affects 32 million children in the world. The economic impact of hearing loss is estimated to cost...
    Resource Type:
    Dissertation
    Full Text:
    Henson, Andrew Bereton, Arden Perkins, Robbert Blizzard, Steve Friedman, Bharath Sunchu, Akash

  • Nanoparticle features and their relative influence on biological responses

    Creator:
    Denluck, Lindsay
    Abstract:
    Nanoparticles (NPs), defined as materials having at least one dimension (height, width, diameter) in the nanoscale, are increasingly being incorporated into a wide variety of products and are replacing traditional bulk materials in many applications. This is because they can be more efficacious, more sustainable, and can have unique characteristics...
    Resource Type:
    Dissertation
    Full Text:
    Bonventre for their advice and mentorship. In particular, I thank Dr. Andrew Buer- meyer for always

  • Mathematical and Experimental Approaches for Designing Less Toxic Cryopreservation Methods

    Creator:
    Warner, Ross M.
    Abstract:
    Successful cryopreservation of all biological specimens would have an untold positive impact on medicine and scientific research. However, cryopreservation of the most complex biological specimens, such as tissues and organs, remains elusive. Vitrification, or ice-free cryopreservation, is promising for cryopreservation of complex specimens. The biggest challenge, though, is the toxicity...
    Resource Type:
    Dissertation
    Full Text:
    lab work. Thank you Jun Yang, Andrew Drake, and Youngjoo Lee for driving with me across the