T cells are one of the key cells in the immune system. Although they are not the first line of defense against a pathogen, their functions can greatly enhance the phagocytosis and destruction of pathogens as well as the development of antibody responses. Furthermore, even when responding T cells have...
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and related compounds are well-recognized for their immunosuppressive activity, which is mediated through an intracellular receptor and transcription factor, aryl hydrocarbon receptor (AhR). Laboratory animals exposed to TCDD are less resistant to infection and have severely impaired humoral and cell-mediated immune responses. This dissertation addressed the hypothesis that...
Although IL-4 is a well-characterized multi-functional cytokine, its role as a survival factor in T cells is not completely understood. In an attempt to uncover IL-4-mediated survival, we studied caspase activation in primary mouse T lymphocytes undergoing death by neglect, activation-induced or steroid-induced cell death. Here, we identify the executioner...
The immune toxicity of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) has been studied for over 35 years, but only recently has the profound immune suppression associated with TCDD exposure been linked to induction of regulatory T cells (Tregs). The effects of TCDD are mediated through binding the aryl hydrocarbon receptor (AhR), a ligand-activated transcription...
The search for the stand density that optimizes growth and hence generates the maximum amount of wood is one of the philosopher’s stone in modern forestry. Since scientific methods were applied to forestry, numerous generations of foresters have studied the relations between stocking density and growth, obtaining diverse results and...
My thesis explores the later work of author J.D. Salinger, including two narratives featured in Nine Stories, "A Perfect Day for Bananafish," and "Teddy," and Franny and Zooey, "Raise High the Roof Beam, Carpenters," and "Seymour: an Introduction." Through my analysis I argue that the religious nature of Salinger's fiction...
This study quantified the magnitude and timing of summer streamflow deficits in paired-watershed experiments in the Cascade Range of Oregon where mature and old-growth conifer forests were subjected to clearcutting, patch cutting, and overstory thinning treatments in the 1960s and 1970s. Hydrologic effects of clearcutting, small-patch cutting, and overstory thinning...
Maximal aerobic capacity (V̇O₂max) is the most widely used measure for assessing cardiorespiratory fitness. It is a strong contributor to performance in endurance sports, predicts functional capacity in older adults, and is related to overall disease risk. As such, it is important that testing methodologies for determining V̇O₂max provide valid...
Small mountainous watersheds are disproportionate sources of land-derived particulate organic matter (POM) to long-term sinks like lake bottoms and the ocean. As such, these ecosystems are an essential component of the global carbon cycle. The burial of POM in lacustrine and marine sediments contributes to the drawdown of atmospheric CO2...
Parasitic infections and immune challenges can affect host reproductive fitness and, ultimately, the evolution of host populations in a myriad of ways. The fitness implications of parasitic infections range from increased host mortality to subtle changes in reproductive investment. From alterations of behaviors, sexual signaling, and competitive ability to changes...