Product design is often driven by customer needs and desires. In this case the customer is the US military, and the desire is to have a cooling unit small enough and light enough to incorporate into hazard suits for use in desert combat. The Micro technology-based Energy and Chemical Systems...
With growing concerns on environment impact of industrial product development, the product developers are seeking better solutions to achieve desired environmental benign requirements by the regulators and customers besides economic growth. During the last decade, some of the most successful product development companies (such as HP) have established their own...
This thesis details my investigation of some pharmaceuticals and natural products on the transport of drugs which are substrates of P-glycoprotein (P-gp), such as cyclosporin A (CSA) and digoxin by using Caco-2 and MDCKII-MDR1 drug transport models. Three objectives were performed to address this goal. The first objective was to...
It is considered best practice when designing pedestrian access at intersections to provide two curb ramps at each street corner. In Oregon, there are many locations where long ramp runs cause curb ramps to be set back a significant distance from the apex of the intersection corner to meet this...
The amorphous to crystalline phase change is of great interest for the production and operation of phase change memory and germanium electronic devices. Phase change memory relies on the ability to differentiate between differences in optical or electrical properties between the amorphous and crystalline phases of a single material. Amorphous...
Molecular genetic and enzymological techniques have been employed to study antibiotic biosynthesis. In this thesis, we studied the formation and modification of the nonproteinogenic amino acid enduracididine (End), which exists in two important antibiotics, mannopeptimycins (MPPs) and enduracidin.
Sequence analysis of the MPP gene cluster revealed that the product of...
Ponderosa pine is an important species both commercially and ecologically in western North America. This study considers the incidence of insect and disease pests on a series of replicated ponderosa pine research plantations in northern California. The studies, on an environmental gradient, contain a series of silvicultural treatments including vegetation...
Systems biology is a powerful approach which considers and sheds light on all of the puzzle pieces which make up complex biological processes, and is an effective alternative to unraveling these processes using traditional molecular approaches alone. It is a natural companion approach for computational biology, which leverages the power...
Microbial ecology has been transformed by metagenomics, the study of the genetic in-formation in entire communities of organisms. In the following we develop metagenomic tools arising from the classic Wasserstein metric as applied to questions regarding the diversity between microbial communities. We provide a novel proof of the characteriza-tion of...
The focus of this thesis is to design, characterize, and apply novel computational methods and molecular systems to interrogate heterogeneous human gut microbiome-related phenomena. In Chapter 2, I design, implement, and characterize a method for embedding co-occurrence patterns derived from massive 16s amplicon datasets. I use this method to 1....