T cells are one of the key cells in the immune system. Although they are not the first line of defense against a pathogen, their functions can greatly enhance the phagocytosis and destruction of pathogens as well as the development of antibody responses. Furthermore, even when responding T cells have...
Although IL-4 is a well-characterized multi-functional cytokine, its role as a survival factor in T cells is not completely understood. In an attempt to uncover IL-4-mediated survival, we studied caspase activation in primary mouse T lymphocytes undergoing death by neglect, activation-induced or steroid-induced cell death. Here, we identify the executioner...
Tobiano is a dominant pattern of white spotting that occurs in certain breeds of horses. This pattern is often desirable and some breeders will purchase a genetic test to help distinguish homozygous from heterozygous horses for breeding purposes. Some tobiano horses have smaller dark spots on the white patches of...
Irradiation experiments are a critical aspect of the nuclear fuels and materials qualification process. Determining the flow conditions of these experiments is necessary for understanding response of nuclear components during transient and normal operation. Quality flow data is lacking for cartridge-type irradiation experiments with annular flow natural circulation designs. Data...
The primary goal of my studies was to elucidate the mechanisms for the well-recognized interaction between two nutrients, vitamins E and K. The outcomes from my studies assess mechanisms for adverse effects of vitamin E and provide novel information on mechanisms for vitamin K homeostasis. These findings will provide information...
Advanced reactor designs offer many advantages over typical Light Water Reactors (LWRs) including fast neutron capability, passive safety features, and improved performance. While the future for these reactors seems promising, operating and test experience is necessary to further validate such claims. The development of full-scale facilities has proved to be...
This thesis provides the first general description of the natural variation in age
structure, growth rates, and survival in headwater populations of coastal cutthroat
trout Oncorhynchus clarkii clarkii from western Oregon, and a subsequent
synthesis of these life-history characteristics across the range of the subspecies.
Age, growth, and survival were...
The United States Pacific Northwest is well known for its shellfish farming. Historically, commercial harvests were dominated by the native Olympia oyster, Ostrea lurida, but over-exploitation, habitat degradation, and competition and predation by non-native species has drastically depleted their densities and extirpated many local populations. As a result, shellfish aquaculture...
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and related compounds are well-recognized for their immunosuppressive activity, which is mediated through an intracellular receptor and transcription factor, aryl hydrocarbon receptor (AhR). Laboratory animals exposed to TCDD are less resistant to infection and have severely impaired humoral and cell-mediated immune responses. This dissertation addressed the hypothesis that...
The commercial groundfish fishing industry and groundfish research have a long concurrent history of activity on the Oregon continental margin. Within the non-whiting groundfish fishery, the target species are primarily flatfishes, sablefish, lingcod, and rockfishes, though landings of each have fluctuated over time. Recent work shows that over the past...