Index Catalog // ScholarsArchive@OSU

Molecular characterization of an HIV-1 drug target and antiviral compound development

Creator:: Maselko, Maciej
Abstract:: The Human Immunodeficiency Virus -1 (HIV-1) has been the source of substantial human misery since it was first discovered in the early 1980s. Despite remarkable progress that has been made towards understanding HIV- 1, there is no cure, no vaccine and life-prolonging therapies are beyond the reach of millions in...
Resource Type:: Dissertation
Full Text:: Antiviral Compound Development. Abstract Approved: Manoj K. Pastey The Human

Harnessing the Potential of Gut Microbiome in the Context of Type 2 Diabetes

Creator:: Gurung, Manoj
Abstract:: Gut microbiota plays an essential role in health and diseases, a fact already established. With the explosive increase in obesity and its main complication, Type 2 Diabetes Mellitus (T2D), there is an immediate need for novel methods of diagnosis, prevention and treatment of these conditions. In the last one and...
Resource Type:: Dissertation
Full Text:: DISSERTATION OF Manoj Gurung for the degree of Doctor of Philosophy in Comparative Health Sciences

Host-pathogen Interactions of Respiratory RNA Viruses and the Application of Recombinase Polymerase Amplification for Viral Diagnostics

Creator:: Prescott, Meagan A.
Abstract:: Humans and viral disease are inextricably intertwined. Viral disease plays an immeasurable role in human life, from the disease and economic burden associated with every facet of contending with human viral disease, to managing the consequences of viral disease in organisms important to our food supply, economy, and entertainment. The...
Resource Type:: Dissertation
Full Text:: : ____________________________________________ Manoj K. Pastey Humans and viral disease are inextricably intertwined. Viral disease

Multiplex real-time PCR in the detection and differentiation of bovine respiratory disease pathogens

Creator:: Zulauf, Brian J.
Abstract:: Bovine respiratory syncytial virus (BRSV), bovine viral diarrhea (BVD) and bovine parainfluenza virus Type 3 (BPI3) are ubiquitous respiratory pathogens of cattle, which contribute to causation of bovine respiratory disease complex. As these respiratory viral pathogens cause very similar clinical symptoms, differential diagnosis of the pathogens is required in one...
Resource Type:: Masters Thesis
Full Text:: Bovine Respiratory Disease Pathogens Abstract approved: Manoj K. Pastey Bovine

Development of Simple, Rapid, and Sensitive qPCR Assay for the Detection of Pseudocapillaria tomentosa in Danio rerio Tissue Samples

Creator:: Ramras, Monique A.
Abstract:: Pseudocapillaria tomentosa is a nematode that parasitizes Danio rerio, causing major disease that affects the economic commodities of fish industries and destroys experimental results at research facilities. There is a critical need for a rapid and sensitive diagnostic assay to test for P. tomentosa in D. rerio populations. PCR primers...
Resource Type:: Honors College Thesis
Full Text:: Samples. Abstract approved:_____________________________________________________ Manoj

RF and Millimeter-wave Techniques to Improve Scalability and Efficiency of Digital Beamforming Arrays

Creator:: Johnson, Manoj
Abstract:: Spectrum overcrowding, ever increasing demand for high data rate and increased mobility requirements are three major challenges 5G-technology is trying to address. In this thesis I start with a RF front-end technique that deals with blocker interference arising from spectrum overcrowding both across frequency bands and within the same frequency...
Resource Type:: Dissertation
Full Text:: AN ABSTRACT OF THE DISSERTATION OF Manoj Johnson for the

Interaction of the Respiratory Syncytial Virus Matrix Protein and the Cellular Adaptor Protein Complex 3µ Subunit

Creator:: Ward, Casey J.
Abstract:: Respiratory Syncytial Virus (RSV) is a leading cause of bronchopneumonia in infants and elderly. Knowledge of viral and host protein interactions is important for better understanding of the viral pathogenesis and may lead to development of novel therapeutic drugs. Here, we show that RSV Matrix (M) protein interacts with cellular...
Resource Type:: Honors College Thesis
Full Text:: Manoj K. Pastey Respiratory Syncytial Virus (RSV) is a leading cause of bronchopneumonia in infants

Targeted development of antivirals against influenza A and respiratory syncytial virus

Creator:: Lupfer, Christopher
Abstract:: Influenza A and Respiratory Syncytial Virus (RSV) are both enveloped, negative strand RNA viruses which infect the respiratory mucosa of animals and humans. Despite decades of research and development of antivirals and vaccines, both of these viruses continue to be a major health concern throughout the world. The focus of...
Resource Type:: Dissertation
Full Text:: : Manoj K. Pastey Influenza A and Respiratory Syncytial Virus (RSV) are both enveloped, negative

Synthesis and function of bioactive, block copolymer surfactant constructs as relevant to the preparation of anticoagulant and antibacterial medical implant surfaces.

Creator:: Joshi, Pranav R.
Abstract:: Nisin, an antibacterial peptide proven to be an effective inhibitor of Gram-positive bacteria, was incorporated into novel block copolymer constructs and tested for retained antibacterial activity. Covalent coupling was achieved by chemical modification of the N-terminal isoleucine to introduce a thiol group. Thiolated nisin derivatives were then linked to poly[ethylene...
Resource Type:: Dissertation
Full Text:: AN ABSTRACT OF THE DISSERTATION OF Pranav R. Joshi for the

Interaction of recombinant factor VIII and the nonionic surfactant Tween 80 at interfaces

Creator:: Joshi, Omkar
Abstract:: The role of the nonionic surfactant Tween 80 on the behavior of the therapeutic recombinant protein Factor VIII (rFVIII) was investigated at solid/liquid and air/water interfaces. In order to provide a model system to compare results obtained for the complicated rFVIII-Tween system, a well-characterized globular protein lysozyme was used. The...
Resource Type:: Dissertation
Full Text:: AN ABSTRACT OF THE DISSERTATiON OF Omkar Joshi for the degree

ScholarsArchive@OSU

Molecular characterization of an HIV-1 drug target and antiviral compound development

Harnessing the Potential of Gut Microbiome in the Context of Type 2 Diabetes

Host-pathogen Interactions of Respiratory RNA Viruses and the Application of Recombinase Polymerase Amplification for Viral Diagnostics

Multiplex real-time PCR in the detection and differentiation of bovine respiratory disease pathogens

Development of Simple, Rapid, and Sensitive qPCR Assay for the Detection of Pseudocapillaria tomentosa in Danio rerio Tissue Samples

RF and Millimeter-wave Techniques to Improve Scalability and Efficiency of Digital Beamforming Arrays

Interaction of the Respiratory Syncytial Virus Matrix Protein and the Cellular Adaptor Protein Complex 3µ Subunit

Targeted development of antivirals against influenza A and respiratory syncytial virus

Synthesis and function of bioactive, block copolymer surfactant constructs as relevant to the preparation of anticoagulant and antibacterial medical implant surfaces.

Interaction of recombinant factor VIII and the nonionic surfactant Tween 80 at interfaces

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