Amyotrophic Lateral Sclerosis (ALS) is a relatively rare neurodegenerative disorder that is fatal 2-4 years after the onset of the disease. Population studies are being done in order to help reveal candidates for further studies of disease etiology, disease progression, as well as to further understand racial and ethnic variations....
Amyotrophic lateral sclerosis (ALS) is a devastating neurological disorder characterized by neuromuscular junction decay, motor neuron death, progressive paralysis, and eventually death of the individual, usually by respiratory failure. Oxidative stress is a prominent hallmark of the disease and is often accompanied and exacerbated by mitochondrial dysfunction and neuroinflammation. This...
In the past two decades, the advancement in data collection and storage have led to the accumulation of complex datasets. Consequently, various industries have sought data-driven solutions to predict and detect anomalies. Temporal patterns have emerged as potential features in prediction models that could improve the performance of the identification...
Amyotrophic lateral sclerosis (ALS) is a devastating disease characterized by the progressive degeneration of motor neurons. Dominantly-inherited mutations to the antioxidant enzyme Cu,Zn superoxide dismutase (SOD1) cause 3-6% of all ALS cases. The complete mechanism behind the toxicity of mutant SOD1 remains unclear, although significant evidence points to aberrant or...
People turn to mass spectrometry to answer some of life’s most important questions. From carbon dating of archeological finds to newborn blood screening tests, mass spectrometry allows us to measure molecules which helps advance our knowledge of life and the world we live in. One area of mass spectrometry that...
Mutations to superoxide dismutase were the first proven cause of Lou
Gehrig’s disease (amyotrophic lateral sclerosis; ALS) implicating superoxide in
the selective death of motor neurons that characterizes ALS. Nitric oxide
competes effectively with superoxide dismutase for superoxide to form the
powerful oxidant peroxynitrite. Endogenous formation of peroxynitrite can kill...
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Joseph S. Beckman
Mutations to superoxide dismutase were the first proven cause of Lou
Health care providers, including complementary and alternative medical (CAM) practitioners, exert a significant influence on parental pediatric vaccination decisions. Use of CAM therapies is increasing in Oregon. Concomitantly, there has been a decade-long increase in parental vaccine refusal in Oregon, rising from 1 to 5 percent from 2000-2009. For example,...
Passage of blood through a sorbent device for removal of bacteria and endotoxin by specific binding with immobilized, membrane-active, bactericidal peptides holds promise for treating severe blood infections. Peptide insertion in the target membrane and stable binding is desirable, while membrane disruption and release of degradation products to the circulating...
Mycobacterium avium subsp. hominissuis (MAH) is a nontuberculous mycobacterium which commonly infects patients with underlying lung pathology. MAH infections are difficult to treat and require lengthy courses of multiple antibiotics. MAH infects macrophages and evade the immune system by altering host cell cytokine production. The hypothesis is that intracellular MAH...
Small organizations may face several management challenges, such as developing non-centralized management structures, knowledge retention in rapid turnover environments, complex operations, and diverse stakeholder requirements. Many methodologies exist to address such management challenges, including viable system model, knowledge management, and Toyota production system, or lean manufacturing. Each of these methodologies...