Sugar phosphate cyclases (SPCs) are enzymes involved in the biosynthesis of many important natural products. SPCs form a unique cyclitol during the early steps in the biosynthesis of many natural products. These natural products include rifamycin, which is chemically modified to rifampicin and used clinically as an antituberculosis drug, and...
T cells are one of the key cells in the immune system. Although they are not the first line of defense against a pathogen, their functions can greatly enhance the phagocytosis and destruction of pathogens as well as the development of antibody responses. Furthermore, even when responding T cells have...
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and related compounds are well-recognized for their immunosuppressive activity, which is mediated through an intracellular receptor and transcription factor, aryl hydrocarbon receptor (AhR). Laboratory animals exposed to TCDD are less resistant to infection and have severely impaired humoral and cell-mediated immune responses. This dissertation addressed the hypothesis that...
Although IL-4 is a well-characterized multi-functional cytokine, its role as a survival factor in T cells is not completely understood. In an attempt to uncover IL-4-mediated survival, we studied caspase activation in primary mouse T lymphocytes undergoing death by neglect, activation-induced or steroid-induced cell death. Here, we identify the executioner...
The immune toxicity of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) has been studied for over 35 years, but only recently has the profound immune suppression associated with TCDD exposure been linked to induction of regulatory T cells (Tregs). The effects of TCDD are mediated through binding the aryl hydrocarbon receptor (AhR), a ligand-activated transcription...
This thesis examines depictions of medievalism in three central texts: Sir Walter Scott's Ivanhoe, Mark Twain's A Connecticut Yankee in King Arthur's Court, and George R.R. Martin's A Game of Thrones. Each of these texts provides an entry point for exploring the ways in which English and American writers have...
The interactions young children have with teachers, peers, and tasks in early care and education (ECE) settings support development of social and academic skills. The degree to which families and teachers partner to support children’s development may contribute to child engagement. The current study aims to expand our understanding of...
Age-related decline in the capacity of endogenous antioxidant systems
complicates pharmaceutical use by the elderly by potentially increasing the toxicity of
some compounds. Of particular interest is chemical detoxification via glutathione (GSH)
and attendant GSH-requiring detoxification enzymes, e.g. GSH peroxidases (GPX) and
GSH S-transferase (GST). These enzymes have been shown...
Families and early care and education (ECE) programs are two important contexts in which young children develop (Bronfenbrenner & Morris, 2006). Nearly half of all preschoolers are cared for in nonrelative care (e.g. child care center, preschool, Head Start, teacher’s home; Laughlin, 2013), and ECE programs have the potential to...
This work compares the condensation heat transfer and pressure drop for zeotropic refrigerant R-454C and its individual components, R-32 and R-1234yf, in horizontal microfin tubes. One microfin tube has a 4 mm outer diameter, 0.18 mm wall thickness, and a surface area ratio of 1.56. The second tube has a...