Experiments were conducted to characterize the nongenomic effects of
progesterone (P4) on binding of oxytocin (OT) to the ovine oxytocin
receptor (OTR) and signal transduction. The dose-response relationship of
P4 to OT binding to the OTR in endometrium was examined. Progesterone
interfered with the binding of OT to the OTR...
Effects of progesterone (P₄) and mifepristone (RU 486) on binding
of oxytocin (OT) to its ovine uterine receptor (OTR) were studied in two
experiments. Two additional experiments were conducted to evaluate
specific binding sites for P4 in endometrial plasma membranes. In Exp.
1, ovariectomized ewes were injected with estradiol-17β (E₂)...
Feeding conjugated linoleic acids (CLA) improves reproductive performance in dairy cows; however, the molecular mechanisms by which CLA improves reproduction are not well understood. Therefore, we evaluated whether the CLA isomers, trans-10, cis-12 CLA and cis-9, trans-11 CLA altered synthesis of steroidogenic hormones in bovine luteal cells by measuring concentrations...