Index Catalog // ScholarsArchive@OSU

Analysis and Expansion of the Role of the Escherichia coli Protein ProQ

Creator:: Sheidy, Daniel T. and Zielke, Ryszard A.
Abstract:: The decrease in proline transport by the proline porter ProP in a Delta proQ strain has been well documented; however, the reason for this phenotype remains undefined. Previous studies have speculated that ProQ facilitates translation of proP mRNA. Here, we demonstrate that ProQ is enriched in the polysome fractions of...
Resource Type:: Article
Full Text:: Analysis and Expansion of the Role of the Escherichia coli

Coibamide A Induces mTOR-Independent Autophagy and Cell Death in Human Glioblastoma Cells

Creator:: Hau, Andrew M., Greenwood, Jeffrey A., Lohr, Christiane V., Serrill, Jeffrey D., Proteau, Philip J., Ganley, Ian G., McPhail, Kerry L., and Ishmael, Jane E.
Abstract:: Coibamide A is an N-methyl-stabilized depsipeptide that was isolated from a marine cyanobacterium as part of an International Cooperative Biodiversity Groups (ICBG) program based in Panama. Previous testing of coibamide A in the NCI in vitro 60 cancer cell line panel revealed a potent anti-proliferative response and "COMPARE-negative" profile indicative...
Resource Type:: Article
Full Text:: America, 4MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dundee

Malonate Inhibits Virulence Gene Expression in Vibrio cholerae

Creator:: Minato, Yusuke, Fassio, Sara R., and Häse, Claudia C.
Abstract:: We previously found that inhibition of the TCA cycle, either through mutations or chemical inhibition, increased toxT transcription in Vibrio cholerae. In this study, we found that the addition of malonate, an inhibitor of succinate dehydrogenase (SDH), decreased toxT transcription in V. cholerae, an observation inconsistent with the previous pattern...
Resource Type:: Article
Full Text:: Sciences, College of Veterinary Medicine, Oregon State University, Corvallis, Oregon, United States of

Proteins Secreted via the Type II Secretion System: Smart Strategies of Vibrio cholerae to Maintain Fitness in Different Ecological Niches

Creator:: Sikora, Aleksandra E.
Abstract:: Many Gram-negative bacteria use the type II secretion (T2S) pathway to deliver proteins that contribute to disease in humans, animals, and plants. Vibrio cholerae, the causative agent of the life-threatening diarrheal disease cholera, utilizes the T2S system for translocation of at least 19 proteins, including the large hexameric protein cholera...
Resource Type:: Article
Full Text:: Aleksandra E. Sikora* Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University

Frequent Alteration of the Tumor Suppressor Gene APC in Sporadic Canine Colorectal Tumors

Creator:: Youmans, Lydia, Taylor, Cynthia, Shin, Edwin, Harrell, Adrienne, Ellis, Angela E., Seguin, Bernard, Ji, Xinglai, and Zhao, Shaying
Abstract:: Sporadic canine colorectal cancers (CRCs) should make excellent models for studying the corresponding human cancers. To molecularly characterize canine CRC, we investigated exonic sequence mutations of adenomatous polyposis coli (APC), the best known tumor suppressor gene of human CRC, in 23 sporadic canine colorectal tumors, including 8 adenomas and 15...
Resource Type:: Article
Full Text:: States of America, 2 College of Veterinary Medicine, University of Georgia, Athens, Georgia, United

Population-Specific Regulation of Chmp2b by Lbx1 during Onset of Synaptogenesis in Lateral Association Interneurons

Creator:: Xu, Jun, Nonogaki, Mariko, Madhira, Ravi, Ma, Hsiao-Yen, Hermanson, Ola, Kioussi, Chrissa, and Gross, Michael K.
Abstract:: Chmp2b is closely related to Vps2, a key component of the yeast protein complex that creates the intralumenal vesicles of multivesicular bodies. Dominant negative mutations in Chmp2b cause autophagosome accumulation and neurodegenerative disease. Loss of Chmp2b causes failure of dendritic spine maturation in cultured neurons. The homeobox gene Lbx1 plays...
Resource Type:: Article
Full Text:: pone.0048573 1..17 Population-Specific Regulation of Chmp2b by

Selective Ablation of Ctip2/Bcl11b in Epidermal Keratinocytes Triggers Atopic Dermatitis-Like Skin Inflammatory Responses in Adult Mice

Creator:: Wang, Zhixing, Zhang, Ling-juan, Guha, Gunjan, Li, Shan, Kyrylkova, Kateryna, Kioussi, Chrissa, Leid, Mark, Ganguli-Indra, Gitali, and Indra, Arup K.
Abstract:: Background: Ctip2 is crucial for epidermal homeostasis and protective barrier formation in developing mouse embryos. Selective ablation of Ctip2 in epidermis leads to increased transepidermal water loss (TEWL), impaired epidermal proliferation, terminal differentiation, as well as altered lipid composition during development. However, little is known about the role of Ctip2...
Resource Type:: Article
Full Text:: Leid1,2,3, Gitali Ganguli-Indra1,2, Arup K. Indra1,2,3,4* 1 Department of Pharmaceutical Sciences, College

Mechanistic Insights into Validoxylamine A 7’-Phosphate Synthesis by VldE Using the Structure of the Entire Product Complex

Creator:: Cavalier, Michael C., Yim, Young-Sun, Asamizu, Shumpei, Neau, David, Almabruk, Khaled H., Mahmud, Taifo, and Lee, Yong-Hwan
Abstract:: The pseudo-glycosyltransferase VldE catalyzes non-glycosidic C-N coupling between an unsaturated cyclitol and a saturated aminocyclitol with the conservation of the stereochemical configuration of the substrates to form validoxylamine A 7'-phosphate, the biosynthetic precursor of the antibiotic validamycin A. To study the molecular basis of its mechanism, the three-dimensional structures of...
Resource Type:: Article
Full Text:: ’-Phosphate Synthesis by VldE Using the Structure of the Entire Product Complex Michael C. Cavalier1., Young

Loss of Abdominal Muscle in Pitx2 Mutants Associated with Altered Axial Specification of Lateral Plate Mesoderm

Creator:: Eng, Diana, Ma, Hsiao-Yen, Xu, Jun, Shih, Hung-Ping, Gross, Michael K., and Kiouss, Chrissa
Abstract:: Correction 17 Oct 2012: Eng D, Ma HY, Xu J, Shih HP, Gross MK, et al. (2012) Correction: Loss of Abdominal Muscle in Pitx2 Mutants Associated with Altered Axial Specification of Lateral Plate Mesoderm. PLOS ONE 7(10): 10.1371/annotation/c980d5a1-1899-4d30-af7b-573d4049cf4b
Resource Type:: Article
Full Text:: , Hung-Ping Shih2, Michael K. Gross1*, Chrissa Kiouss1* 1 Department of Pharmaceutical Sciences, College

Regulation of Motility of Myogenic Cells in Filling Limb Muscle Anlagen by Pitx2

Creator:: Campbell, Adam L., Shih, Hung-Ping, Xu, Jun, Gross, Michael K., and Kioussi, Chrissa
Abstract:: Cells of the ventrolateral dermomyotome delaminate and migrate into the limb buds where they give rise to all muscles of the limbs. The migratory cells proliferate and form myoblasts, which withdraw from the cell cycle to become terminally differentiated myocytes. The myogenic lineage colonizes pre-patterned regions to form muscle anlagen...
Resource Type:: Article
Full Text:: , Chrissa Kioussi1* 1 Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University

ScholarsArchive@OSU

Analysis and Expansion of the Role of the Escherichia coli Protein ProQ

Coibamide A Induces mTOR-Independent Autophagy and Cell Death in Human Glioblastoma Cells

Malonate Inhibits Virulence Gene Expression in Vibrio cholerae

Proteins Secreted via the Type II Secretion System: Smart Strategies of Vibrio cholerae to Maintain Fitness in Different Ecological Niches

Frequent Alteration of the Tumor Suppressor Gene APC in Sporadic Canine Colorectal Tumors

Population-Specific Regulation of Chmp2b by Lbx1 during Onset of Synaptogenesis in Lateral Association Interneurons

Selective Ablation of Ctip2/Bcl11b in Epidermal Keratinocytes Triggers Atopic Dermatitis-Like Skin Inflammatory Responses in Adult Mice

Mechanistic Insights into Validoxylamine A 7’-Phosphate Synthesis by VldE Using the Structure of the Entire Product Complex

Loss of Abdominal Muscle in Pitx2 Mutants Associated with Altered Axial Specification of Lateral Plate Mesoderm

Regulation of Motility of Myogenic Cells in Filling Limb Muscle Anlagen by Pitx2

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