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Effect of digestion on stability of palivizumab IgG1 in the infant gastrointestinal tract

Creator:

Lueangsakulthai, Jiraporn, Kim, Bum Jin, Demers-Mathieu, Veronique, Sah, Baidya Nath P., Woo, Yeonhee, Olyaei, Amy, Aloia, Molly, O'Connor, Ann, Scottoline, Brian P., and Dallas, David C.

Abstract:

Background Potentially, orally administered antibodies specific to enteric pathogens could be administered to infants to prevent diarrheal infections, particularly in developing countries where diarrhea is a major problem. However, to prevent infection, such antibodies would need to resist degradation within the gastrointestinal tract. Methods Palivizumab, a recombinant antibody specific to...

Resource Type:

Article

Full Text:

stability of palivizumab IgG1 in the infant gastrointestinal tract Jiraporn Lueangsakulthai1, Bum Jin Kim1