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Drug Hypersensitivity: How Drugs Stimulate T Cells via Pharmacological Interaction with Immune Receptors

Creator:

Pichler, Werner J., Adam, Jacqueline, Watkins, Stephen, Wuillemin, Natascha, Yun, James, and Yerly, Daniel

Abstract:

Small chemicals like drugs tend to bind to proteins via noncovalent bonds, e.g. hydrogen bonds, salt bridges or electrostatic interactions. Some chemicals interact with other molecules than the actual target ligand, representing so-called ‘off-target' activities of drugs. Such interactions are a main cause of adverse side effects to drugs and...

Resource Type:

Article

Full Text:

stimulate an immune reaction under certain circumstances [68] . A po- tential role of small molecules as a