Index Catalog // ScholarsArchive@OSU

Impact of Polycyclic Aromatic Hydrocarbons on Barrier Function Toxicity in 3D Lung Model from Normal and Asthmatic Donor Cells

Creator:: Huynh, Celine T.
Abstract:: Polycyclic aromatic hydrocarbons (PAHs) are known to cause adverse health effects in the human lung. Here, we evaluated biomarkers relevant for PAH toxicity in a 3D human primary bronchial epithelial cell (HBEC) model collected from normal and asthmatic donors. We previously found that PAHs decrease cellular barrier function integrity, which...
Resource Type:: Honors College Thesis
Full Text:: Function Toxicity in 3D Lung Model from Normal and Asthmatic Donor Cells by Celine Huynh

Gene regulatory mechanisms of the lncRNA Fendrr

Creator:: Koehler, Monika
Abstract:: Embryonic development, where organs and major structures begin to develop, requires precise coordination of numerous gene regulatory pathways. Fendrr is an long non-coding RNA (lncRNA) that plays a role in regulating gene expression in mesodermal tissues during early embryonic development in mouse. The lateral plate mesoderm (LPM) is an earlier...
Resource Type:: Presentation and Undergraduate Thesis
Full Text:: involved in gene regulation through triplex interactions with genomic DNA  Focused on the lung derived

Understanding polycyclic aromatic hydrocarbon (PAH) toxicity and inflammation in human bronchial epithelial cells

Creator:: Valdez, Teresa
Abstract:: There is increased emphasis on understanding cumulative risk from the combined effects of chemical and non-chemical stressors as it relates to public health. Recent animal studies have identified pulmonary inflammation as a possible modifier and risk factor for chemical toxicity in the lung after exposure to inhaled pollutants; however, little...
Resource Type:: Honors College Thesis
Full Text:: in the lung after exposure to inhaled pollutants; however, little is known about specific

Toxicity and Mutagenicity of Polycyclic Aromatic Hydrocarbons in Contaminated Soils using Mammalian In Vitro Assay

Creator:: Luker, George W.
Abstract:: There exists a growing need to establish a better in vitro model for evaluating PAH toxicity and carcinogenicity and to improve assessments of risk to human health, especially to the complex mixtures that exist in the environment. Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous environmental contaminants due to the incomplete combustion...
Resource Type:: Presentation
Full Text:: of DNA-Adducts implicated in lung cancer •How do we identify the carcinogenic potential? Zhang

Functional consequences of microRNA regulation by polycyclic aromatic hydrocarbons in 3D human bronchial epithelial cells

Creator:: Mans, Michael-Andres D.
Abstract:: Polycyclic aromatic hydrocarbons (PAHs) are a class of contaminants ubiquitous in the environment and result from the incomplete combustion of fossil fuels. Many PAHs have been identified as procarcinogenic, and are metabolized to form DNA adducts; however, other mechanisms also may contribute to toxicity and help explain differences in toxicity...
Resource Type:: Undergraduate Thesis
Full Text:: response to BAP, cigarette smoke, and pollution-related lung diseases and cancers. The 3D HBEC model

Genotyping Cytochrome P450 1B1*3(Phase I) and Glutathione S-transferase Mu 1 null (Phase II), Metabolizing Enzymes in a [14C]Benzo[a]pyrene Human Micro Dosing Study

Creator:: Luo, Yun L.
Abstract:: Polycyclic Aromatic Hydrocarbons (PAHs) have been studied for their carcinogenic toxicity. PAHs are formed by incomplete carbon combustion. Benzo[a]pyrene (BaP) is an IARC classified Class 1 Human carcinogenic PAH. New studies are conducted to gain a better understanding of PAHs and how to reduce exposure. Glutathione S-transferase M 1 (GSTM1...
Resource Type:: Honors College Thesis
Full Text:: (Chang et al., 2013). A prevalent CYP1B1 SNP associated with increased cancer incidence is the CYP1B1*3

Enhancing Protocols to Improve Consistency Across Nanotoxicology Studies

Creator:: Luker, Sabrina R.
Abstract:: In current nanotoxicology research, there is a lack of standardization in reporting of zebrafish exposure media and sonication practices. This lack of standardization in use and reporting methods has made reproducing nanoparticle (NP) toxicity results between labs a common issue. It is important to have a standardized way of reporting...
Resource Type:: Undergraduate Thesis
Full Text:: , 40 kHz 450 1000 Yes MQ (Zhu, Chang, & Chen, 2010) Al2O3 ultrasonicator (Sonics, USA

MatTek™ EpiIntestinal™ a 3D Small Intestine Epithelial Cell Culture Model For In Vitro Screening in Dietary Chemopreventive Agents

Creator:: Raymundo, Wilfrido E.
Abstract:: Testing the many potential chemoprevention agents from dietary sources in animal or human models is expensive and takes a long time. In vitro models can be useful for screening the right compounds to use in larger studies. We tested the MatTek™ EpiIntestinal™ small intestine epithelial 3D cell culture model for...
Resource Type:: Undergraduate Thesis
Full Text:: barrier. Chang et al. (2019) also saw a decrease in TEER values in a 3D lung epithelial model dosed 48

De novo Discovery of Novel Long Noncoding RNAs in the North American Beaver

Creator:: Kashyap, Amita
Abstract:: Long noncoding RNAs (lncRNAs) are RNA molecules that are at least 200 nucleotides long and do not encode proteins. lncRNAs have roles in gene regulation, chromatin epigenetics, and molecular scaffolding. In light of mounting evidence implicating species-specific noncoding RNAs and gene regulatory mechanisms in species adaptations, it is reasonable to...
Resource Type:: Honors College Thesis
Full Text:: , Ramsey Lab RNA came from 16 tissues • Heart • Liver • Lung • Intestine • Ovaries • Castor gland

Using Acetylene as a Low-cost and Effective Methanogenesis Inhibitor in Single Chamber Microbial Electrolysis Cells

Creator:: Trujillo, Stephanie
Abstract:: Microbial electrolysis cells (MECs) for hydrogen production exhibit great advantages over many other biohydrogen production techniques in terms of versatility of substrate and hydrogen yield. However, hydrogen scavenging by methanogens put forward a great challenge to the application of the single chamber MECs when using mixed culture. Various strategies were...
Resource Type:: Undergraduate Thesis
Full Text:: .; Ajayi, F.F.; Chang, I.S. Selective inhibition of methanogens for the improvement of biohydrogen

ScholarsArchive@OSU

Impact of Polycyclic Aromatic Hydrocarbons on Barrier Function Toxicity in 3D Lung Model from Normal and Asthmatic Donor Cells

Gene regulatory mechanisms of the lncRNA Fendrr

Understanding polycyclic aromatic hydrocarbon (PAH) toxicity and inflammation in human bronchial epithelial cells

Toxicity and Mutagenicity of Polycyclic Aromatic Hydrocarbons in Contaminated Soils using Mammalian In Vitro Assay

Functional consequences of microRNA regulation by polycyclic aromatic hydrocarbons in 3D human bronchial epithelial cells

Genotyping Cytochrome P450 1B1*3(Phase I) and Glutathione S-transferase Mu 1 null (Phase II), Metabolizing Enzymes in a [14C]Benzo[a]pyrene Human Micro Dosing Study

Enhancing Protocols to Improve Consistency Across Nanotoxicology Studies

MatTek™ EpiIntestinal™ a 3D Small Intestine Epithelial Cell Culture Model For In Vitro Screening in Dietary Chemopreventive Agents

De novo Discovery of Novel Long Noncoding RNAs in the North American Beaver

Using Acetylene as a Low-cost and Effective Methanogenesis Inhibitor in Single Chamber Microbial Electrolysis Cells

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