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Absorption of benzocaine -³H from semi-solid dosage forms following rectal administration in rats

Creator:: Lorskulsint, Duangchit
Abstract:: The effect of concentration, vehicle and surfactant on the absorption of benzocaine -³H across the rat's rectal mucosa was investigated. Blood radioactivity levels were determined after the application of benzociane -³H containing suppositories and ointments. A wet oxidation method was used for sample digestion. Since the radioactivity counted is the...
Resource Type:: Masters Thesis
Full Text:: Duangchit Lorskulsint ACKNOWLEDGMENT I would like to express my deepest gratitude to Dr. J. W. Ayres for

Preformulation studies with 1, 3-bis (2-chloroethyl)-1-nitrosourea (NSC 409962)

Creator:: Laskar, Paul A.
Abstract:: The stability of 1 3-bis(2-chloroethyl)-1-nitrosourea (NSC 409962)(BCNU) was investigated in several buffered aqueous media, in mixed solvent and in nonaqueous solvent systems, and in the presence of several electrolytes and nonelectrolytes. The degradation rate constant of BCNU in these systems was calculated from the parameters of the linear regression of...
Resource Type:: Dissertation
Full Text:: privacy Dr. James W. All The stability of 1 3-bis(2-chloroethyl)-1-nitrosourea (NSC 409962)(BCNU) was

Bioavailability and pharmacokinetics of dyphylline and theophylline in rabbits

Creator:: Mayo, Charles Edward
Abstract:: The bioavailability and pharmacokinetics of theophylline in rabbits were determined following both oral and intravenous administration of the drug. Serum theophylline concentrations were determined using high pressure liquid chromatography. Pharmacokinetic parameters were determined and verified by computer analysis. The overall mean Beta disposition constant was 0.089 hr⁻¹ which corresponds to...
Resource Type:: Masters Thesis
Full Text:: DYPHYLLINE AND THEOPHYLLINE IN RABBITS Abstract approved: Redacted for Privacy Dr. James W. Ayres V Part

Comparative pharmacokinetic studies of dyphylline and some dyphylline prodrugs

Creator:: Huang, Hua-pin
Abstract:: Dyphylline is an analog of theophylline and the latter is the most popular member of the methylxanthine family in use for the treatment of asthma. Although dyphylline is devoid of some problems associated with theophylline, a reported short half-life has made it's clinical usefulness limited. To avoid this problem a...
Resource Type:: Masters Thesis
Full Text:: ....- v,....- ,-...- Dr. James W. Ayre i Dyphylline is an analog of theophylline and the latter is the

Prolonged duration of action of dyphylline through prodrugs

Creator:: Panomvana, Duangchit
Resource Type:: Dissertation
Full Text:: . Redacted for privacyAbstract approved: ?'Dr. James W. Ayres A series of four diesJrs and four monoesters

Assay and pharmacokinetics of dyphylline following oral administration in humans

Creator:: Gisclon, Lee Gehl
Abstract:: Improved assay methods for determination of dyphylline levels in plasma, saliva, and urine utilizing high pressure liquid chromatography have been developed. Detection of levels as low as 25 ng/ml from 0.5 ml plasma and 50 ng/ml from 0.5 ml saliva were possible. Both procedures utilized the same extraction process. A...
Resource Type:: Masters Thesis
Full Text:: ORAL ADMINISTRATION IN HUMANS Abstract approved: Redacted for privacy James W. Ayr4s(e7.D. Improved

Chelating agents in the drug dosage design of iron preparations

Creator:: Ghannam, Musa
Abstract:: The role of iron in the body is well known for it is a component of hemoglobin, myoglobin, cytochrome, enzyme catalase and peroxidase. Iron deficiency anemia is widespread among vulnerable groups in industrialized societies and in the general population of tropical developing areas. In the United States there are ten...
Resource Type:: Masters Thesis
Full Text:: ACKNOWLEDGMENTS I would like to express my deepest appreciation to Dr. J. W. Ayres who was an excellent advisor

Pharmacokinetic investigation of a potential drug interaction : aminophylline and prednisone

Creator:: Anderson, John L.
Resource Type:: Masters Thesis
Full Text:: Potential Drug Interaction: Aminophylline and Prednisone Abstract approved: Redacted for Privacy es W

The effect of food and tablet age on the relative bioavailability and pharmacodynamics of two tolbutamide products

Creator:: Olson, Stephen Carl
Abstract:: The relative bioavailability and pharmacodynamics of tolbutamide from two different commercially available tablet products has been evaluated in healthy subjects in a single dose cross over study. Products were aged by exposing tablets to 98% relative humidity for 3 days at ambient temperature which was found to differentially affect both...
Resource Type:: Dissertation
Full Text:: PRODUCTS Abstract Approved: Redacted for Privacy James W. Ayres, PhiDO The relative bioavailability and

Pharmacokinetics of dyphylline after administration of prodrugs in rabbits and pigs

Creator:: Huang, Hua-pin
Abstract:: Dyphylline is an analogue of theophylline and the latter is the most popular member of the methyixanthine family in use for the treatment of asthma. Although dyphylline is devoid of some problems associated with theophylline, a reported short half-life for dyphylline (2.1 hours) has made its clinical usefulness limited. In...
Resource Type:: Dissertation
Full Text:: Administration of Prodrugs in Rabbits and Pigs Abstract approved: Redacted for privacy/ mJaes W. Ayres, P1

ScholarsArchive@OSU

Absorption of benzocaine -³H from semi-solid dosage forms following rectal administration in rats

Preformulation studies with 1, 3-bis (2-chloroethyl)-1-nitrosourea (NSC 409962)

Bioavailability and pharmacokinetics of dyphylline and theophylline in rabbits

Comparative pharmacokinetic studies of dyphylline and some dyphylline prodrugs

Prolonged duration of action of dyphylline through prodrugs

Assay and pharmacokinetics of dyphylline following oral administration in humans

Chelating agents in the drug dosage design of iron preparations

Pharmacokinetic investigation of a potential drug interaction : aminophylline and prednisone

The effect of food and tablet age on the relative bioavailability and pharmacodynamics of two tolbutamide products

Pharmacokinetics of dyphylline after administration of prodrugs in rabbits and pigs

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