Index Catalog // ScholarsArchive@OSU

Antimicrobial peptide regulation by small molecules in humans and other primates

Creator:: Sinnott, Brian D.
Abstract:: Antimicrobial peptides (AMPs) play an important role in the innate immune system. Determining the pathways by which these proteins are regulated allows for modulation of their expression for better health. Two families of antimicrobial peptides have been studied in humans: cathelicidins and defensins. There is a single cathelicidin in humans...
Resource Type:: Masters Thesis
Full Text:: other Primates Abstract approved: Adrian F. Gombart Antimicrobial peptides (AMPs) play

Transcriptional regulation of the human cathelicidin antimicrobial peptide gene

Creator:: Guo, Chunxiao
Abstract:: Human cathelicidin antimicrobial peptide (CAMP/LL-37) is a cationic antimicrobial peptide that is widely expressed by myeloid and epithelial cells at the human-environment interface. It possesses broad spectrum antimicrobial capacity against bacteria, fungi and viruses. In addition to its direct antimicrobial activity, CAMP/LL-37 also attracts and recruits monocytes, neutrophils and other...
Resource Type:: Dissertation
Full Text:: Cathelicidin Antimicrobial Peptide Gene. Abstract approved: Adrian F. Gombart Human cathelicidin

The effect of dietary compounds on human cathelicidin antimicrobial peptide gene expression mediated through farnesoid X receptor and its potential role in gastrointestinal health

Creator:: Campbell, Yan
Abstract:: The human cathelicidin antimicrobial peptide (CAMP) is a broad spectrum microbicidal agent and modulator of both the innate and adaptive immune system. It is induced by 1,25-dihydroxyvitamin D (1,25(OH)₂D₃) through activation of the vitamin D receptor (VDR) and primary bile salts through activation of the xenobiotic nuclear receptor farnesoid X...
Resource Type:: Dissertation
Full Text:: approved: Adrian F. Gombart The human cathelicidin antimicrobial peptide (CAMP) is a broad spectrum

OpMNPV p32, a baculovirus polyhedral envelope-associated protein : genetic location, nucleotide sequence, transcriptional mapping and immunocytochemical characterization

Creator:: Gombart, Adrian F.
Abstract:: Baculoviruses comprise a diverse group of pathogens infectious for members of the insect orders Lepidoptera, Hymenoptera and Diptera. Of the three subgroups, two (subgroup A, nuclear polyhedrosis virus (NPV) and subgroup B, granulosis virus (GV) are occluded in a crystalline protein structure while the remaining subgroup (subgroup C, non-occluded virus)...
Resource Type:: Masters Thesis
Full Text:: characterization AN ABSTRACT OF THE THESIS OF Adrian F. Gombart for the degree of Master of Science in Genetics

Mass spectrometry techniques to assess the metabolism and toxicity of pharmaceutical and dietary nitrates

Creator:: Axton, Elizabeth R.
Abstract:: Nitric oxide (NO) is a signaling molecule that regulates blood pressure and vascular tone. Humans produce NO by endothelial nitric oxide synthase (eNOS), which is impaired in patients with cardiovascular disease leading to increased blood pressure, endothelial dysfunction, and an increased risk of adverse cardiovascular outcomes. Maintaining optimal levels of...
Resource Type:: Dissertation
Full Text:: Kioussi, and Adrian Fritz Gombart for their helpful feedback, support, and guidance. Thank you to all

The effect of ascorbate on enzymatic nitroglycerin bioactivation as measured by direct LC-MS/MS determination of nitrite

Creator:: Hardardt, Elizabeth Ann
Abstract:: This work sought to characterize a link between Vitamin C and nitroglycerin at the level of enzymatic bioactivation. Before we could proceed, we needed to develop a method that sensitively and selectively identified the product of bioactivation, nitrite. We successfully adapted traditional diaminonaphthalene derivatization with the use of stable isotope...
Resource Type:: Masters Thesis
Full Text:: ” Rochefort, Phil Proteau and Adrian “Fritz” Gombart, and all the researchers who developed the use of

Characterization of novel exopolysaccharide producing lactic acid bacteria

Creator:: Garcia, Roberto A., III
Abstract:: Lactic Acid Bacteria (LAB), an important group of organisms in modern food production, are known to secrete a unique compound called exopolysaccharide (EPS). EPS is economically important because it enhances functional properties in food and may confer beneficial health effects to consumers. Novel strains of Lactococcus lactis, Streptococcus thermophilus, and...
Resource Type:: Masters Thesis
Full Text:: thanks to my committee members, Dr. Theo Dreher, Dr. Bruce Geller, and Dr. Adrian Gombart, for their

Regulation of BCL11B by post-translational modifications

Creator:: Liu, Xiao
Abstract:: Bcl11b (B-cell lymphoma/leukemia 11b), also known as Ctip2 (Chicken ovalbumin upstream promoter transcription factor (COUP-TF)-interacting protein 2), is a C2H2 zinc finger transcriptional regulatory protein, which is an essential protein for post-natal life in the mouse and plays crucial roles in the development, and presumably function, of several organ systems,...
Resource Type:: Masters Thesis
Full Text:: . Filtz, Dr. Taifo Mahmud, and Dr. Adrian F. Gombart for serving on my committee and for their advice

Mechanisms that influence the posttranslational modification of the GluN2B subunit in the aged brain

Creator:: Zamzow, Daniel R.
Abstract:: Memory is essential to everyday life. As we age, deficits in memory become apparent. The toll of age-related cognitive impairment can be devastating to families and costly to society. The NMDA receptor is a molecule in the brain that is instrumental in the formation of memories. The receptor is particularly...
Resource Type:: Dissertation
Full Text:: good friend and colleague. I would like to thank my committee members: Fritz Gombart, Pat Chappell

Age-related loss of Nrf2, a novel mechanism for the potential attenuation of xenobiotic detoxification capacity

Creator:: Smith, Eric Jonathan
Abstract:: Nuclear Factor, Erythroid Derived 2, Like 2 (NFE2L2 or Nrf2) is the primary transcription factor in cellular defense against oxidative and xenobiotic stresses in higher eukaryotes. This basic leucine zipper transcription factor regulates over 200 antioxidant, detoxification, and lipid metabolizing genes by binding to the Antioxidant Response Element (ARE; a...
Resource Type:: Dissertation
Full Text:: AUTHORS I would like to acknowledge Dr. Gary F. Merrill for guidance in the execution and

ScholarsArchive@OSU

Antimicrobial peptide regulation by small molecules in humans and other primates

Transcriptional regulation of the human cathelicidin antimicrobial peptide gene

The effect of dietary compounds on human cathelicidin antimicrobial peptide gene expression mediated through farnesoid X receptor and its potential role in gastrointestinal health

OpMNPV p32, a baculovirus polyhedral envelope-associated protein : genetic location, nucleotide sequence, transcriptional mapping and immunocytochemical characterization

Mass spectrometry techniques to assess the metabolism and toxicity of pharmaceutical and dietary nitrates

The effect of ascorbate on enzymatic nitroglycerin bioactivation as measured by direct LC-MS/MS determination of nitrite

Characterization of novel exopolysaccharide producing lactic acid bacteria

Regulation of BCL11B by post-translational modifications

Mechanisms that influence the posttranslational modification of the GluN2B subunit in the aged brain

Age-related loss of Nrf2, a novel mechanism for the potential attenuation of xenobiotic detoxification capacity

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