Index Catalog // ScholarsArchive@OSU

Generation of expression plasmids to study the function of the PRC2 subunit Suz12 in Fusarium graminearum

Creator:: Park, Catherine
Abstract:: The Polycomb Repressive Complex 2 (PRC2) catalyzes genome transcription repression through the methylation of lysine residue 27 in the amino terminal region of histone 3 (H3K27me1/2/3) [2], [7]. PRC2 is made up of three highly conserved core subunits: Kmt6, Eed, and Suz12. Accurate distribution of PRC2 is essential for proper...
Resource Type:: Honors College Thesis
Full Text:: , 2002): 1039–43. (4) Connolly, Lanelle R., Kristina M. Smith, and Michael Freitag. “The Fusarium

A Panel of Histone H3 Mutations to Investigate Centromere Maintenance and Gene Silencing

Creator:: Geisler, Mark S.
Abstract:: Histones, as part of nucleosomes, are responsible for DNA packaging in chromosomes. They also affect DNA expression by a multitude of post-translational modifications, especially prevalent on the amino terminus of histones. Co-activator protein complexes “write”, “read”, or “erase” histone modifications, and in balance determine which sections of DNA are free...
Resource Type:: Honors College Thesis
Full Text:: . Abstract approved:___________________________________________ Michael Freitag Histones, as

The role of the putative transcription factor DIS10 in PRC2-mediated gene silencing

Creator:: Jackson, Kendra K.
Abstract:: PRC2 (Polycomb Repressive Complex 2) mediated gene silencing plays an important role in cell differentiation, stem cell plasticity, and tumor suppression. In fungi, it is also involved in pathogenicity. The catalytic subunit, KMT6, trimethylates lysine 27 on histone h3 (H3K27me3) at loci targeted for silencing. In animals, PRC1 and PRC2...
Resource Type:: Honors College Thesis
Full Text:: :_____________________________________________________ Michael Freitag PRC2 (Polycomb Repressive Complex 2) mediated gene silencing plays an

Mutation of Polycomb Repressive Complex 2 (PRC2) kmt6 to Probe in vivo Function in Fusarium

Creator:: Josephson, Brian
Abstract:: Polycomb Repressive Complex 2 (PRC2) is a histone methyltransferase that initiates facultative heterochromatin formation by trimethylating histone H3 on lysine 27 (H3K27me3). Mutations within its three primary subunits, KMT6, EED, and SUZ12, result in inherited diseases and sporadic cancers. In the fungus Fusarium graminearum, deletion of the gene encoding the...
Resource Type:: Honors College Thesis
Full Text:: . Connolly, L. R., Smith, K. M., and Freitag, M. (2013) The Fusarium graminearum Histone H3 K27

Mutations of CenH3 Domains and their Effect on Chromocenter Localization and Meiosis in Neurospora crassa

Creator:: Ferrer, Sarah Theresa
Abstract:: In recent years, non-coding DNA has received much attention within the scientific community. This attention has not only illuminated the mystery behind functionally important regions like the centromere, but has also brought to light additional important questions regarding centromere mechanisms, inheritance, and cellular recognition by the kinetochore, a protein complex...
Resource Type:: Honors College Thesis
Full Text:: N. crassa CenH3 gene (S. Friedman, S. Ferrer, P. Phatale, M. Freitag, unpublished data). 22

Exploring Chromodomain Genes in the Fungus Fusarium graminearum Through Targeted Genetic Manipulation

Creator:: Peters, Alec
Abstract:: DNA segments in the fungus Fusarium graminearum were identified as possible genes encoding for chromodomain proteins (CDPs), and targeted for genetic manipulation. Targeted single-gene deletion strains, as wells as GFP-S tag fusion strains, were generated from wildtype F. graminearum protoplasts, and verified strains were screened for phenotypic differences, such as...
Resource Type:: Honors College Thesis
Full Text:: . Connolly, LR, Smith KM, Freitag, M (2013) “The Fusarium graminearum Histone H3 K27 Methyltransferase KMT6

Inter-code Comparison of Time Independent Pulsed Sphere Benchmark Results

Creator:: Northrop, Jordan
Abstract:: The pulsed sphere benchmark problems are a set of physical experiments that have been used to verify Monte Carlo codes and evaluate nuclear data. All Monte Carlo codes rely on benchmark experiments that test the features of the code to verify that the simulations are producing realistic results. In the...
Resource Type:: Honors College Thesis
Full Text:: approved: Camille Palmer The pulsed sphere benchmark problems are a set of physical experiments that have

Investigation of the Effects of Commercial Salmon Fishery Management in Upper Cook Inlet, Alaska

Creator:: Fleming-Craig, Danielle
Abstract:: Optimal commercial fishery management sustains each salmon species' population while maximizing economic benefits. This thesis addresses two questions. What are the Alaska Department of Fish and Game's and the Board of Fisheries' intentions when conducting a fishery management plan in Upper Cook Inlet? How does it compare to its implementation?...
Resource Type:: Honors College Thesis
Full Text:: _____________________________________________________________________ Camille Soltau Nelson, Committee Member, representing Economics

Investigating Local Energy Compensation of Adjacent RNA Secondary Structures in the bpRNA-1m Database

Creator:: Cornwell-Arquitt, Robert L.
Abstract:: Non-coding ribonucleic acid (ncRNA) is of interest for its diverse roles in cell and viral biology. RNA molecules vary greatly in terms of size, structure, and function. In recent years, the modification of existing RNA structures has been used for biochemical methods of enormous impact including CRISPR and RNAi methods....
Resource Type:: Honors College Thesis
Full Text:: _____________________________________________________________________ Michael Freitag, Committee Member, representing Biochemistry and Biophysics

Regulation of the Pantoea agglomerans type III secretion system by plant-exuded sugars

Creator:: Bacher, Daniel
Abstract:: Pantoea agglomerans pathovar betae (Pab) is a bacterium that causes galls on the roots of beet plants, resulting in reduced marketability of beet roots and crop loss. Pab uses a type III secretion system (T3SS) to infect and cause galls on beets. The T3SS is a molecular syringe-like structure that...
Resource Type:: Honors College Thesis
Full Text:: _____________________________________________________________________ Michael Freitag, Committee Member, representing Biochemistry and Biophysics

ScholarsArchive@OSU

Generation of expression plasmids to study the function of the PRC2 subunit Suz12 in Fusarium graminearum

A Panel of Histone H3 Mutations to Investigate Centromere Maintenance and Gene Silencing

The role of the putative transcription factor DIS10 in PRC2-mediated gene silencing

Mutation of Polycomb Repressive Complex 2 (PRC2) kmt6 to Probe in vivo Function in Fusarium

Mutations of CenH3 Domains and their Effect on Chromocenter Localization and Meiosis in Neurospora crassa

Exploring Chromodomain Genes in the Fungus Fusarium graminearum Through Targeted Genetic Manipulation

Inter-code Comparison of Time Independent Pulsed Sphere Benchmark Results

Investigation of the Effects of Commercial Salmon Fishery Management in Upper Cook Inlet, Alaska

Investigating Local Energy Compensation of Adjacent RNA Secondary Structures in the bpRNA-1m Database

Regulation of the Pantoea agglomerans type III secretion system by plant-exuded sugars

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