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Filtering by: Creator Minato, Yusuke Non-Academic Affiliation Oregon State University. Undergraduate Research, Scholarship, and the Arts (URSA)

Characterization of the Na⁺-transporting NADH:ubiquinone oxidoreductase (NQR) in Vibrio cholerae

Creator:

Fassio, Sara R., Minato, Yusuke, Quinn, Matthew J., Faulkner, Wyatt J., and Hase, Claudia C.

Abstract:

We previously reported that inhibition of the Na⁺ translocating NADH:ubiquinone oxidoreductase (NQR), either by chemical inhibition or mutation, increased toxT transcription in Vibrio cholerae. In this study, we revealed that the nqr mutant strain showed similar phenotypes as the Escherichia coli NADH dehydrogenase I (nuo) mutant strain (e.g. growth defect...

Resource Type:

Poster
Sodium/Proton Antiporter Activity is Essential for Virulence of Yersinia pestis

Creator:

Faulkner, Wyatt J., Ghosh, Amit, Minato, Yusuke, Winogrodzki, Judith, Lind, Erin, Plano, Gregory V., Hinnebusch, Joseph B., Dibrov, Pavel, and Häse, Claudia C.

Abstract:

We found that a strains of Yersinia pestis (KIM5) which lacked the nhaA gene was fully attenuated in a plague model. This gene produces a protein of the sodium-proton antiporter family which expel sodium ions from the bacterial cytoplasm in exchange for hydrogen ions, or protons, from the surrounding environment....

Resource Type:

Poster