Index Catalog // ScholarsArchive@OSU

Dissecting DNA Damage Responses in Arabidopsis: A High-Throughput Sequencing Approach

Creator:: Brar, Anantnoor K., Wilcox, Buck W. L., Curtis, Marc, and Hays, John B.
Abstract:: Cells are constantly bombarded with mutagens, both endogenous and exogenous in origin. Endogenous sources of mutation include reactive oxygen species formed during aerobic respiration, replication errors by DNA polymerase, and spontaneous deamination and depurination (Jackson 2009). Exogenous sources of mutation include UV and ionizing radiation, aflatoxins, and polycyclic aromatic hydrocarbons...
Resource Type:: Honors College Thesis
Full Text:: , Marc Curtis3, and John B. Hays2, 4 1Department of Biochemistry and Biophysics, 2Environmental and

Effects of DNA mismatch repair inhibition in Arabidopsis thaliana

Creator:: Wilcox, Buck W. L.
Abstract:: Genomic instability underlies diseases of unregulated cell growth that result in cancers and developmental abnormalities in humans. Similar genome destabilizing mechanisms are used to create genetic variety in crops for use in breeding and trait development. Errors that occur during DNA replication may cause mutations if they are not corrected...
Resource Type:: Dissertation
Full Text:: Inhibition in Arabidopsis thaliana. Abstract approved: John B. Hays Genomic instability

An assay for screening cells for mismatch repair proficiency in vivo

Creator:: Wu, Shiau-Yin
Abstract:: Mismatch repair is one of the mechanisms by which cells ensure genomic stability. Deficiencies in mismatch repair (MMR) increase mutation rates and cancer risks. In the well-characterized methyl-directed Escherichia co/i system, MMR is initiated by MutS, Mut L, and MutH proteins. The single MutS protein and the single MutL protein...
Resource Type:: Masters Thesis
Full Text:: ACKNOWLEDGEMENT Special thanks to my major advisor Dr. John Hays, and my committee members; Dr. Christopher

Reversion reporters in Arabidopsis thaliana to detect all six base substitution pathways

Creator:: Bollmann, Stephanie R.
Abstract:: Maintaining genome integrity is essential for an organism, as mutation accumulation can lead to cancer, reduced fitness, and heritable diseases in offspring. Therefore the study of mutations, how they are induced, and how they are prevented is vital. Biomonitor systems are useful for understanding the relevant biological effects of a...
Resource Type:: Dissertation
Full Text:: : _____________________________________________________________________ John B. Hays Maintaining genome integrity is essential for an organism, as mutation

Dissecting DNA Damage Responses in Arabidopsis: A High-Throughput Sequencing Approach

Creator:: Brar, Anantnoor
Abstract:: A unique, permanent root-growth arrest phenotype was observed in UV-B irradiated Arabidopsis thaliana roots lacking the DNA damage response kinase ATR. Segregation analysis suggests the dependence of this phenotype on another, unidentified gene, termed ursu. High-throughput sequencing technologies were used to map and identify the causal ursu mutation. Illumina HiSeq...
Resource Type:: Honors College Thesis
Full Text:: : ____________________________________________________ John B. Hays A unique, permanent root-growth arrest phenotype was observed in UV-B

Repression of DNA Mismatch Repair (MMR) in Arabidopsis thaliana through Dominant-Negative MMR Proteins

Creator:: Mohamed, Aly
Abstract:: The highly conserved multi-protein mismatch repair (MMR) system is known for its ability to correct post replication errors in genomic DNA. A hallmark of MMR deficiency in all organisms is microsatellite instability. The initiating proteins in the eukaryotic MMR system are hetrodimers formed with an integral MSH2 subunit and one...
Resource Type:: Honors College Thesis
Full Text:: :_____________________________________________________ John B. Hays The highly conserved multi-protein mismatch repair (MMR) system is known for its

The bacteriophage P1 bof protein : a corepressor whose action can both negatively and positively affect phage gene expression

Creator:: Schaefer, Timothy S.
Resource Type:: Dissertation
Full Text:: Affect Phage Gene Expression. Abstract approved. i Redacted for Privacy John B. Hays The complex

Recombinagenic and anti-mutagenic processing of UV-light photoproducts by the Escherichia coli methyl-directed mismatch-repair system

Creator:: Feng, Wen-yang
Resource Type:: Dissertation
Full Text:: System Abstract approved: John B. ays Genetic recombination of UV-irradiated nonreplicating 2 phage

Isolation and characterization of DNA-damage-repair/toleration genes from Arabidopsis thaliana

Creator:: Pang, Qishen
Resource Type:: Dissertation
Full Text:: my Professor, Dr. John Hays for his guidance and support. His creative ideas which initiated these

Mismatch repair in plants : identification and characterization of Arabidopsis thaliana MutS homolog proteins

Creator:: Culligan, Kevin M.
Resource Type:: Dissertation
Full Text:: Proteins. Abstract approved: John B. Hays All eukaryotic organisms examined thus far encode homologs of

ScholarsArchive@OSU

Dissecting DNA Damage Responses in Arabidopsis: A High-Throughput Sequencing Approach

Effects of DNA mismatch repair inhibition in Arabidopsis thaliana

An assay for screening cells for mismatch repair proficiency in vivo

Reversion reporters in Arabidopsis thaliana to detect all six base substitution pathways

Dissecting DNA Damage Responses in Arabidopsis: A High-Throughput Sequencing Approach

Repression of DNA Mismatch Repair (MMR) in Arabidopsis thaliana through Dominant-Negative MMR Proteins

The bacteriophage P1 bof protein : a corepressor whose action can both negatively and positively affect phage gene expression

Recombinagenic and anti-mutagenic processing of UV-light photoproducts by the Escherichia coli methyl-directed mismatch-repair system

Isolation and characterization of DNA-damage-repair/toleration genes from Arabidopsis thaliana

Mismatch repair in plants : identification and characterization of Arabidopsis thaliana MutS homolog proteins

Limit your search

Academic Affiliation

Advisor

Commencement Year

Committee Member

Conference Name

Conference Section/Track

Creator

Contributor

Date

Decade

Degree Field

Degree Level

Degree Name

File Format

Funding Body

Language

License

Location

Non-Academic Affiliation

Peer Reviewed

Resource Type

Rights Statement

Subject

Search Constraints

Search Results

Limit your search