Index Catalog // ScholarsArchive@OSU

Oligoribonucleotides directed at ribosomal protein binding sites as inhibitors of ribosomal small subunit assembly and as possible antibiotics

Creator:: Thompson, Cynthia Sue
Abstract:: The effects of oligoribonucleotides of identical or similar sequences to a ribosomal protein binding site, specifically S8, on prokaryotic 30S ribosomal assembly were investigated in Escherichia coli. The oligoribonucleotides were expected to bind to the target protein S8 and block its incorporation into the 30S subunit, resulting in a nonfunctional...
Resource Type:: Dissertation
Full Text:: long, depending on the species. In E. coli, S8 is 129 amino acids long with a molecular weight of

Synthesis and oligomerization of Delta, 4-diamino-2-oxo-1(2H)-pyrimidinehexanoic acid

Creator:: Huang, Sung-ben
Resource Type:: Dissertation
Full Text:: , optically pure propanoic acids, substituted at the 2-position with nucleic acid bases, have been prepared

Nucleic acid polymerases associated with neoplasms

Creator:: Kiessling, Ann Drue
Abstract:: RNA tumor viruses, such as avian myeloblastosis virus (AMV) and MC29 virus, cause malignant transformation of the cells they infect. Transformed cells are able to continually produce progeny virus particles. Evidence is given that RNA-dependent RNA polymerase is present in virus infected cells. RNA-dependent RNA polymerase isolated from AMV-infected myeloblasts...
Resource Type:: Dissertation
Full Text:: (Bonar and Beard, 1959). The nucleic acid is composed of several species: 1) a high molecular weight RNA

Nucleic Acid Based Therapeutics for Treatment of Cystic Fibrosis

Creator:: McKinney, Madison J.
Abstract:: Cystic fibrosis is an inherited genetic disease caused by a single gene mutation in the CFTR protein. Affecting 70,000 people worldwide, this disease is debilitating to patients, resulting in persistent lung infections and decreased quality of life. Due to the various mutation types, there is not currently a single drug...
Resource Type:: Honors College Thesis
Full Text:: Nucleic Acid Based Therapeutics for Treatment of Cystic

Characterization of photochemically cross-linked protein-nucleic acid complexes by mass spectrometry

Creator:: Jensen, Ole Norregaard
Abstract:: A novel protocol for the study of protein-nucleic acid interactions is presented and demonstrated to be feasible. The protocol combines photochemical crosslinking techniques and mass spectrometric methods into a new strategy for identifying protein domains or amino acid residues that are in close contact with nucleic acid in protein-nucleic acid...
Resource Type:: Dissertation
Full Text:: determination of intact, UV-crosslinked protein-nucleic acid complexes and for molecular weight determination

Fluorescence studies on the bases of the nucleic acids in solution at room temperature

Creator:: Hauswirth, William Walter
Abstract:: Fluorescence of adenine, guanine, thymine, cytosine, and uracil has been detected at room temperature in neutral aqueous solution using a digital signal accumulation technique and right angle fluorescence detection from solutions with absorbances between 0. 4 and 0. 7. The quantum yields are respectively 2.6 x 10⁻⁴, 3.0 x 10⁻⁴,...
Resource Type:: Dissertation
Full Text:: Fluorescence studies on the bases of the nucleic acids in

The hydrolysis of desoxyribonucleic acid derived from salmon sperm

Creator:: Dille, Kenneth Leroy
Resource Type:: Masters Thesis
Full Text:: nucleic acids, that the paranucleic acid prepared from fish EE8 was found to be identical to that from e

Intercalation on hydrocarbons in polynucleotides

Creator:: Craig, Albert Morrie
Abstract:: The binding of eleven polycyclic, aromatic hydrocarbons to the acid form of poly A has been investigated. The hydrocarbons were chosen to test a size criterion. Model building showed that some hydrocarbons could intercalate in the helix and be well protected from contact with the aqueous solvent. Experimentally it was...
Resource Type:: Dissertation
Full Text:: polycyclic, aromatic hydrocarbons to the acid form of poly A has been investigated. The hydrocarbons were

Spectrophotometric determination of nuclear desoxyribonucleic acid in selected tissues of Taricha (Triturus) granulosa granulosa Skilton

Creator:: Truong Thi-Hue, Simone
Resource Type:: Masters Thesis
Full Text:: ) GRANULOSA GRANULOSM SKILTON INTRODUCTI ON Desoxyriboso nucleic acid (DNA) has been known for sorne time

The effects of pH on the torsional flexibility of DNA bound to a nucleosome core particle

Creator:: Winzeler, Elizabeth A.
Abstract:: The effects of pH on the torsional flexibility of DNA bound to a nucleosome core particle were investigated by studying the time-resolved fluorescence anisotropy decays of ethidium bromide intercalated into the DNA of the core particle. As the torsional flexibility of DNA is affected by the presence of an intercalating...
Resource Type:: Masters Thesis
Full Text:: the molecular level in the past two decades have been astounding, there still remains a great deal of

ScholarsArchive@OSU

Oligoribonucleotides directed at ribosomal protein binding sites as inhibitors of ribosomal small subunit assembly and as possible antibiotics

Synthesis and oligomerization of Delta, 4-diamino-2-oxo-1(2H)-pyrimidinehexanoic acid

Nucleic acid polymerases associated with neoplasms

Nucleic Acid Based Therapeutics for Treatment of Cystic Fibrosis

Characterization of photochemically cross-linked protein-nucleic acid complexes by mass spectrometry

Fluorescence studies on the bases of the nucleic acids in solution at room temperature

The hydrolysis of desoxyribonucleic acid derived from salmon sperm

Intercalation on hydrocarbons in polynucleotides

Spectrophotometric determination of nuclear desoxyribonucleic acid in selected tissues of Taricha (Triturus) granulosa granulosa Skilton

The effects of pH on the torsional flexibility of DNA bound to a nucleosome core particle

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