Index Catalog // ScholarsArchive@OSU

Vitellogenesis : a biomarker for estrogenic and antiestrogenic effects of organochlorines in rainbow trout

Creator:: Donohoe, Regina M.
Abstract:: Persistent organochlorines (OCs) bioaccumulate in aquatic biota and potentially impair reproduction via endocrine disruption. The present research evaluated estrogenic effects of the OCs, chlordecone (CD) and o,p'-DDT/DDE, and the antiestrogenicity of 3,4,5,3',4',5'-hexachlorobiphenyl (345-HCB) in juvenile rainbow trout, utilizing vitellogenesis as a biomarker. Vitellogenesis, estrogen regulated hepatic production of the yolk...
Resource Type:: Dissertation
Full Text:: . Schaup and Dr. Mark T. Zabriskie. This work would not have been possible without the generous

Application of modern NMR techniques to structure elucidation of bioactive natural products from tunicates

Creator:: Sikorska, Justyna
Abstract:: Recent developments in NMR hardware have extended the reach of natural products chemists to structure elucidation of compounds isolated on a nanomolar scale. In parallel with advances in hardware new NMR techniques for structure elucidation have evolved, e.g. quantitative NOEs, residual dipolar couplings (RDCs)and diffusion-ordered spectroscopy (DOSY). The application of...
Resource Type:: Dissertation
Full Text:: my own projects. I also wish to acknowledge Dr. Philip J. Proteau and Dr. Mark Zabriskie for their

Expanding the scope of a Diels-Alder approach to biaryl synthesis

Creator:: Schwartz, Johanna Perkins
Abstract:: A Diels-Alder approach to biaryls (DAB) has been applied towards the synthesis of highly substituted, programmable biaryl templates. Tri- and tetra-ortho-substituted biaryls can be produced in just three to four steps from commercially available materials utilizing the Diels-Alder [4+2] cycloaddition. The methods described herein will illustrate the ability of mono...
Resource Type:: Dissertation
Full Text:: , Prof. Paul R. Blakemore, Prof. Kevin P. Gable, Prof. Mark Zabriskie, and Prof. Kaichang Li for their

Synthesis of novel ambifunctional atropisomeric 2,2',6,6'-tetrasubstituted biphenyls and investigation of their properties and organocatalytic activity

Creator:: Sephton, Mark Alan
Abstract:: Ambifunctional axially chiral 2,2',6,6'-tetrasubstituted biphenyls containing nucleophilic (or basic) functional groups juxtaposed with hydrogen-bond donors were synthesized and their properties studied. Applications for the prepared biaryls as potential organocatalysts for enantioselective carbon-carbon bond forming reactions were examined. Processes investigated included: aldol, Michael, nitroaldol (Henry), and Baylis-Hillman reactions. The novel amidoamine...
Resource Type:: Dissertation
Full Text:: AN ABSTRACT OF THE DISSERTATION OF Mark Alan Sephton for the degree of Doctor of Philosophy

Control of p53 tumor suppressor and peroxiredoxin activity through shifts incellular redox balance

Creator:: Stoner, Christopher S.
Abstract:: Aerobic organisms have evolved many sensory mechanisms that allow response to oxidants in the environment. One area of interest is the relationship between the activity of the tumor suppressor protein p53 and the redox state of thioredoxin. Human p53 activity is severely compromised in budding yeast lacking thioredoxin reductase. Evidence...
Resource Type:: Dissertation

Comparison and optimization of chromatographic conditions for separation of cyclic dynorphin A analogues from linear byproducts

Creator:: Leelasvatanakij, Leena
Resource Type:: Masters Thesis
Full Text:: . Thirdly, I would like to acknowledge my committee members, Dr. Michael W. Schuyler, Dr. T. Mark Zabriskie

Novel oxylipins and other bioactive metabolites from marine algae

Creator:: Nagle, Dale George
Abstract:: I have participated in a drug discovery program designed to screen marine algae for inhibitors of cancer-related enzymes, antitumor compounds, antiinflammatory substances, and other agents of potential pharmaceutical utility. Over 1,500 lipid and aqueous extracts of marine plants and animals were surveyed for biomedical potential. Assays designed to screen extracts...
Resource Type:: Dissertation
Full Text:: . De Lander, T. Mark Zabriskie, Thomas F. Savage, and George H. Constantine for their valuable

Biosynthetic studies of fungal diterpene antibiotics

Creator:: Yao, Qingmei
Abstract:: The isoprenoid pathway is one of the major biosynthetic pathways of secondary metabolites. Isoprenoids with a C₂₀ skeleton are known as diterpenoids and are derived from the common precursor, geranylgeranyl diphosphate (GGPP). This dissertation describes approaches to discover the diterpene synthase enzymes which provide the backbone structures for pleuromutilin and...
Resource Type:: Masters Thesis
Full Text:: , guidance, and patience in this research project and dissertation. I would also like to thank Dr. T. Mark

Biologically Active Secondary Metabolites from Red Sea Cyanobacteria

Creator:: Alhadab, Ali A.
Abstract:: This project describes the investigation of marine cyanobacteria collected from the Red Sea with an emphasis on the identification and prioritization of biologically active fractions for future purification and molecular structure elucidation of medicinally relevant secondary metabolites. Five crude extracts of taxonomically unidentified Red Sea cyanobacteria supplied by Egyptian collaborators...
Resource Type:: Honors College Thesis
Full Text:: Mark Zabriskie ALHADA01 Typewritten Text Christopher Thornburg ACKNOWLEDGMENTS First, I

Synthesis and opioid activity of dynorphin analogues with the modifications in the message sequence

Creator:: Kulkarni, Sandhya N.
Resource Type:: Masters Thesis
Full Text:: members, Dr. Douglas Barofsky, Dr. Mark Zabriskie and Dr. Markle Douglas. I appreciate the cooperation

ScholarsArchive@OSU

Vitellogenesis : a biomarker for estrogenic and antiestrogenic effects of organochlorines in rainbow trout

Application of modern NMR techniques to structure elucidation of bioactive natural products from tunicates

Expanding the scope of a Diels-Alder approach to biaryl synthesis

Synthesis of novel ambifunctional atropisomeric 2,2',6,6'-tetrasubstituted biphenyls and investigation of their properties and organocatalytic activity

Control of p53 tumor suppressor and peroxiredoxin activity through shifts incellular redox balance

Comparison and optimization of chromatographic conditions for separation of cyclic dynorphin A analogues from linear byproducts

Novel oxylipins and other bioactive metabolites from marine algae

Biosynthetic studies of fungal diterpene antibiotics

Biologically Active Secondary Metabolites from Red Sea Cyanobacteria

Synthesis and opioid activity of dynorphin analogues with the modifications in the message sequence

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