Index Catalog // ScholarsArchive@OSU

Exogenous gene expression from heterologous promoters in fish cell cultures

Creator:: Sharps, Angela
Abstract:: Cell culture systems have provided many insights into eukaryotic gene expression and other biochemical mechanisms. Since the cell represents the smallest living unit of any organism it provides a desirable in vitro system, allowing biochemical studies without the complex physiology of an entire animal. However, processes involving intracellular mechanisms, such...
Resource Type:: Masters Thesis
Full Text:: and regulation The function of DNA is to carry the genetic message from generation to generation and

Assessment of fluorinated chemicals (FCs) on developmental toxicity in embryonic zebrafish

Creator:: Duong, Lisa
Abstract:: Fluorinated chemicals (FCs) have been used since the 1950s in many industrial and commercial applications because of their unique properties such as chemical inertness, resistance to heat and their ability to repel water and oils. Concerns regarding potential environmental or human health risk from FCs exposure have emerged due to...
Resource Type:: Masters Thesis
Full Text:: to developmental toxicity. 6 Zebrafish (Danio rerio) as an ideal model The available

Chemical and biological approaches to identify vertebrate tissue regeneration pathways

Creator:: Sengupta, Sumitra
Abstract:: Numerous human conditions would be improved if therapies to encourage tissue regeneration were available. The goal of regenerative medicine is to encourage the body's intrinsic ability to repair and restore tissues lost by disease, injury or aging. While certain vertebrates have the inherent capacity to regenerate, mammals do not. To...
Resource Type:: Dissertation
Full Text:: and spinal cord. The organization of the genome and the genetic pathways involved with signal

Case studies : Using the zebrafish to evaluate neurobehavioral phenotypes

Creator:: Garcia, Abraham, Truong, Lisa, Johnson, Eric, Tanguay, Robert L., and Knecht, Andrea
Abstract:: The use of zebrafish in behavioral neuroscience is rapidly growing. Zebrafish can be assessed for alterations in multiple behavioral endpoints, creating opportunities to use this powerful model to identify chemicals that alter behavioral phenotypes. To evaluate the utility of zebrafish for neurotoxicity research, we designed custom instrumentation to evaluate numerous...
Resource Type:: Undergraduate Thesis and Presentation

Size- and Oxidation-Dependent Toxicity of Graphene Oxide Nanomaterials in Embryonic Zebrafish

Creator:: Lopez, Ryan
Abstract:: Graphene and its derivatives are two-dimensional hexagonal lattices that possess desirable physicochemical properties leading to an ever-expanding list of industrial and biomedical uses. Graphene oxides (GOs) are becoming a popular graphene alternative and while there have been human safety studies, investigations of developmental toxicity are lacking. The use of distinct...
Resource Type:: Masters Thesis
Full Text:: environment. Zebrafish (Danio rerio) have become a well-established model in toxicological studies due to

Optimizing Methods to Assess Nanoparticle Biodistribution in Embryonic Zebrafish

Creator:: Pfarr, Shaylin H.
Abstract:: As nanoparticle (NP) research and development expands, the significance of NP biodistribution effects on toxicity increases. A reliable method for measuring NP biodistribution is critical. Hyperspectral Imaging (HSI) is capable of accurately quantitating NP biodistribution within embryonic zebrafish with incredibly high precision. Before HSI processing, the embryo must be sectioned...
Resource Type:: Honors College Thesis

Nitrate and Nitrite Differentially Affect Respiration in Zebrafish During Exercise

Creator:: Logan, Christiana R.
Abstract:: A decline in the oxygen cost of exercise enhances exercise tolerance and performance. Substantial research has shown that dietary nitrate lowers the oxygen cost of exercise in sedentary humans; however, the metabolic determinants regarding how dietary nitrate influences oxygen consumption in skeletal muscle is not known. We addressed this gap...
Resource Type:: Honors College Thesis
Full Text:: employing a zebrafish (Danio rerio) model to study the effect of nitrate and nitrite supplementation. We

Pseudoloma neurophilia in the Zebrafish (Danio rerio) : Consequences of Infection on Neurobehavioral and Biomedical Research using a Burgeoning Model Organism

Creator:: Spagnoli, Sean
Abstract:: Since its inception as a laboratory animal in the early 1970s, the zebrafish has proven itself a rising star in the world of comparative biomedical sciences due to its short generation time, ease of care, external fertilization, and transparent larvae. In a very few decades, the zebrafish has been utilized...
Resource Type:: Dissertation
Full Text:: Health Sciences presented on May 27, 2016 Title: Pseudoloma neurophilia in the Zebrafish (Danio

Establishing Larval Zebrafish as an In Vivo Model Organism for Characterizing the Roles of Otoferlin, a Sensory Hair Cell Protein Essential for Hearing

Creator:: Chatterjee, Paroma
Abstract:: Auditory defects and disorders are prevalent at all ages and affect 8% of the population in developed nations including newborns and children. Congenital hearing loss is the most common birth defect and it is estimated that 1 in 1000 children are affected by deafness at birth or before the onset...
Resource Type:: Dissertation
Full Text:: associated symptoms. More than two- thirds of non-syndromic hearing loss cases are of genetic origin, with

Evaluation of zebrafish (Brachydanio rerio) as a model for carcinogenesis

Creator:: Tsai, Hsi-Wen
Abstract:: Zebrafish (Brachydanio rerio) are small, freshwater teleost fishes in the family Cyprinidae, the true minnows. They are native to the tropical latitudes of India, but have become widespread through their use as aquarium fish and as models for several branches of biological research. Their ease of rearing, short generation time,...
Resource Type:: Dissertation
Full Text:: 49 CHAPTER 3: THE CARCINOGENICITY OF DIETARY AFLATOXIN B, TO ZEBRAFISH {Brachydanio danio) AND

ScholarsArchive@OSU

Exogenous gene expression from heterologous promoters in fish cell cultures

Assessment of fluorinated chemicals (FCs) on developmental toxicity in embryonic zebrafish

Chemical and biological approaches to identify vertebrate tissue regeneration pathways

Case studies : Using the zebrafish to evaluate neurobehavioral phenotypes

Size- and Oxidation-Dependent Toxicity of Graphene Oxide Nanomaterials in Embryonic Zebrafish

Optimizing Methods to Assess Nanoparticle Biodistribution in Embryonic Zebrafish

Nitrate and Nitrite Differentially Affect Respiration in Zebrafish During Exercise

Pseudoloma neurophilia in the Zebrafish (Danio rerio) : Consequences of Infection on Neurobehavioral and Biomedical Research using a Burgeoning Model Organism

Establishing Larval Zebrafish as an In Vivo Model Organism for Characterizing the Roles of Otoferlin, a Sensory Hair Cell Protein Essential for Hearing

Evaluation of zebrafish (Brachydanio rerio) as a model for carcinogenesis

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