Soil is an important, dynamic component of regional and global mercury (Hg) cycles. This study evaluated how changes in forest soil Hg masses caused by atmospheric deposition and wildfire are affected by forest structure. Pre and postfire soil Hg measurements were made over two decades on replicate experimental units of...
Changes in soil C and N pools following wildfire are quite varied, but there is little understanding of the causes of the variation. We examined how the legacies of prefire ecosystem structure may explain the variation in soil trajectories during the first decade following wildfire. Five years prior to wildfire...
Early-successional stages have been truncated and altered in many western U.S. forest landscapes by planting conifers, controlling competing vegetation, suppressing fire, and focusing on maintaining late-seral species and undisturbed riparian zones. Declining area of early-successional stages may be reducing resilience and sustainability on landscapes that experience elevated disturbance related to...
Antarctic krill are a key component of the diet of Adélie penguins inhabiting the Western Antarctic Peninsula (WAP), yet our understanding of the variability of krill distribution patterns within nearshore penguin feeding grounds is limited. A recent study of the foraging patterns of penguins breeding in the northern WAP suggests...
Background:
Osteosarcoma (OS) is an aggressive and often fatal cancer that afflicts over 1000 humans and 10,000 dogs per year in the United States. Recent evidence suggests deregulation in the signaling triad, receptor activator of nuclear factor kappa B (RANK), its activating ligand (RANKL), and the RANKL inhibitor, osteoprotegerin (OPG)...
While the marketing literature has advocated for decades that new products should be designed for intended and
anticipated consumer usages, the engineering literature mostly proposes optimization of product performances
independent of specific users’ skills, anticipated usage scenarios, and competing products on the market. In contrast
to tedious market studies which...
BACKGROUND: This investigation sought to elucidate the relationship between hepatocyte growth factor (HGF)–induced metastatic behavior and the tyrosine kinase inhibitors (TKIs) crizotinib and dasatinib in canine osteosarcoma (OS). Preliminary evidence of an apparent clinical benefit from adjuvant therapy with dasatinib in four dogs is described. METHODS: The inhibitors were assessed...
Background: Osteosarcoma (OS) affects over 8000 dogs/year in the United States. The disease usually arises in the appendicular skeleton and metastasizes to the lung. Dogs with localized appendicular disease benefit from limb amputation and chemotherapy but most die within 6–12 months despite these treatments. Taurolidine, a derivative of taurine, has...
Background: Osteosarcoma in dogs and humans share many similarities and the dog has been described as an excellent model to study this disease. The median survival in dogs has not improved in the last 25 years. Taurolidine has been shown to be cytotoxic to canine and human osteosarcoma in vitro....