Marine bacteria from the SAR11 clade (class Alphaproteobacteria), specifically strains
HTCC1062 and HTCC7211, were characterized according to a polyphasic taxonomic approach.
Maximum cell densities and growth rates at various temperatures, salinities, and pH’s were
analyzed. Strains HTCC1062 and HTCC7211 were observed as having different growth
optimums. On the basis of...
BACKGROUND:
AVI-7288 is a phosphorodiamidate morpholino oligomer with positive charges that targets the viral messenger RNA that encodes Marburg virus (MARV) nucleoprotein. Its safety in humans is undetermined.
METHODS:
We assessed the efficacy of AVI-7288 in a series of studies involving a lethal challenge with MARV in nonhuman primates. The...