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Polyphasic taxonomy of marine bacteria from the SAR11 group Ia: Pelagibacter ubiquis (strain HTCC1062) & Pelagibacter bermudensis (strain HTCC7211)

Creator:

Brown, Sarah N., Giovannoni, Stephen, and Cho, Jang-Cheon

Abstract:

Marine bacteria from the SAR11 clade (class Alphaproteobacteria), specifically strains HTCC1062 and HTCC7211, were characterized according to a polyphasic taxonomic approach. Maximum cell densities and growth rates at various temperatures, salinities, and pH’s were analyzed. Strains HTCC1062 and HTCC7211 were observed as having different growth optimums. On the basis of...

Resource Type:

Article and Presentation
AVI-7288 for Marburg Virus in Nonhuman Primates and Humans

Creator:

Heald, Alison E., Charleston, Jay S., Iversen, Patrick L., Warren, Travis K., Saoud, Jay B., Al-Ibrahim, Mohamed, Wells, Jay, Warfield, Kelly L., Swenson, Dana L., Welch, Lisa S., Sazani, Peter, Wong, Michael, Berry, Diane, Kaye, Edward M., and Bavari, Sina

Abstract:

BACKGROUND: AVI-7288 is a phosphorodiamidate morpholino oligomer with positive charges that targets the viral messenger RNA that encodes Marburg virus (MARV) nucleoprotein. Its safety in humans is undetermined. METHODS: We assessed the efficacy of AVI-7288 in a series of studies involving a lethal challenge with MARV in nonhuman primates. The...

Resource Type:

Article and Presentation