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Chiral synthesis of monic acid C

Creator:: Theramongkol, Parinya
Abstract:: Bromoalkoxylation of dihydropyran with bromine and 1-borneol, followed by dehydrobromination and epoxidation, afforded trans-2-1- bornyloxy-3,4-epoxytetrahydropyran as a major product. This was treated with sodium phenylselenide to give a 1:1 mixture of (2R,3R,4R)- 2-1-bornyloxy-3-hydroxy-4-phenylselenotetrahydropyran and its (2S,3S, 4S) diastereomer. Elimination of the selenoxide, derived from oxidation of the former with hydrogen...
Resource Type:: Dissertation
Full Text:: observed low toxicity of the antibiotic in mammals. (a) (b) Hydrophobic HO OH Hydrophobic co

Synthetic studies on the macrolide antibiotic rutamycin B

Creator:: Wang, Shan
Resource Type:: Dissertation
Full Text:: Synthetic studies on the macrolide antibiotic rutamycin B AN

Advanced studies on the biosynthesis of the streptolidine moiety of streptothricin F

Creator:: Jackson, Michael D.
Resource Type:: Dissertation
Full Text:: nucleoside antibiotic produced by Streptomyces Iavendulae var. L-1689-23. The biosynthesis of the

Studies of the biosynthesis of Sarubicin A

Creator:: Eisenberg, Rodney L.
Abstract:: Early studies on the biosynthesis of Sarubicin A, 1, had suggested the intermediacy of the novel aromatic amino acid 6-hydroxyanthranilic acid, 17. To investigate the biosynthetic steps beyond 17, [¹³C-¹⁵N carboxamide] 6-hydroxyanthranilamide, 27a, was synthesized, and fed to fermentations of Streptomyces helicus. Incorporation of 27a into 1 provided suggestive evidence...
Resource Type:: Dissertation
Full Text:: napthoquinone antibiotic, has the 2-oxabicyclo[2.2.2]oct-5-ene structure in common with 1.6 The antibiotic G

Part I: Total synthesis of marine macrolide amphidinolide F and synthetic studies toward amphidinolide C; Part II: Computational study on proline sulfonamide-catalyzed aldol reaction

Creator:: Mahapatra, Subham
Abstract:: More than 30 members of the diverse amphidinolide family of biologically active macrolides have been isolated over last three decades. From this family, amphidinolides C and F stand among the most complex and densely functionalized affiliates. Recently, we have accomplished the first total synthesis of amphidinolide F. The all-carbon framework...
Resource Type:: Dissertation

Biosyntheis of Blasticidin S : pathway and enzymes for the nucleoside formation and blastidic acid assembly

Creator:: Guo, Jincan
Resource Type:: Dissertation
Full Text:: approved: Dr. Ste Irn J. Gould Blasticidin S (BS) is an antifungal antibiotic produced by Streptomyces

Biosynthesis and modification of the antibiotic enduracidin

Creator:: Goebel, Neal C.
Abstract:: The continued propagation of antibiotic resistance requires the development of new therapeutics. The lipopeptide antibiotic enduracidin has demonstrated high activity against Gram-positive pathogens including methicillin-resistant Staphylococcus aureus. In addition to a lack of cross-resistance with existing antibiotic classes, enduracidin has no known transferrable resistance mechanism. The development of enduracidin as...
Resource Type:: Dissertation
Full Text:: , 2012. Title: Biosynthesis and Modification of the Antibiotic Enduracidin Abstract approved: T. Mark

Studies on naphthyridinomycin biosynthesis

Creator:: He, Weixuan
Resource Type:: Dissertation
Full Text:: revealed another compound, 8, with strong antibiotic activities as well. High resolution mass spectra and

Advanced studies of blasticidin S biosynthesis

Creator:: Zhang, Qibo
Resource Type:: Dissertation
Full Text:: S (BS, 1) is a peptidyl nucleoside antibiotic produced by Streptomyces griseochromogenes. The

Studies toward the total synthesis of sanglifehrin A

Creator:: Suttisintong, Khomson
Abstract:: Studies toward synthesis of subunits of sanglifehrin A, an immunosuppressant featuring a highly substituted [5,5]-spirolactam moiety as well as a 22-membered macrocycle are described. The macrolactone contains a peptidic backbone characterized by an unusual [beta]-substituted (S)-piperazic acid and (S)-m-hydroxyphenylalanine units. These studies resulted in the synthesis of advanced intermediate 358...
Resource Type:: Dissertation

ScholarsArchive@OSU

Chiral synthesis of monic acid C

Synthetic studies on the macrolide antibiotic rutamycin B

Advanced studies on the biosynthesis of the streptolidine moiety of streptothricin F

Studies of the biosynthesis of Sarubicin A

Part I: Total synthesis of marine macrolide amphidinolide F and synthetic studies toward amphidinolide C; Part II: Computational study on proline sulfonamide-catalyzed aldol reaction

Biosyntheis of Blasticidin S : pathway and enzymes for the nucleoside formation and blastidic acid assembly

Biosynthesis and modification of the antibiotic enduracidin

Studies on naphthyridinomycin biosynthesis

Advanced studies of blasticidin S biosynthesis

Studies toward the total synthesis of sanglifehrin A

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