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Filtering by: Subject Developmental genetics Resource Type Dissertation

Characterization of the mechanism and function of C₂H₂ zinc finger protein CTIP2 in the developmental processes

Creator:

Golonzhka, Olga

Abstract:

CTIP2 is a C2H2 zinc finger transcription factor that plays important yet poorly understood roles in mouse development. CTIP2 is known to be highly expressed in the central nervous system, skin and T lymphocytes during embryogenesis. CTIP2-null mice die perinatally of unknown causes and exhibit defects in multiple organ systems...

Resource Type:

Dissertation

Full Text:

play a central role in controlling the developmental processes. The genetic programs governed by
Developmental toxicity of polycyclic aromatic hydrocarbons : defining mechanisms with systems-based transcriptional profiling

Creator:

Goodale, Britton C.

Abstract:

Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous in the environment as components of fossil fuels and by-products of combustion. Defining toxicity mechanisms for this large family of multi-ring structures and substituted derivatives is a substantial challenge. Several PAHs, such as benzo(a)pyrene (BaP), are mutagenic, toxic to wildlife, and classified as probable...

Resource Type:

Dissertation

Full Text:

Developmental Toxicity of Polycyclic Aromatic Hydrocarbons
Consequences of miRNA misregulation on embryonic development and aging

Creator:

Franzosa, Jill A.

Abstract:

microRNAs (miRNAs), ~21-24 nucleotide-long RNAs that post-transcriptionally regulate gene expression, have rapidly become one of the most extensively studied mechanisms of the past decade. Since their discovery as temporal regulators of post-embryonic development in C. elegans, miRNAs have been functionally implicated in almost every cellular process investigated to date. miRNAs...

Resource Type:

Dissertation

Full Text:

developmental stages. First, to uncover the potential role of miRNAs in teratogenicity, we investigated