Sugar phosphate cyclases (SPCs) are enzymes involved in the biosynthesis of many important natural products. SPCs form a unique cyclitol during the early steps in the biosynthesis of many natural products. These natural products include rifamycin, which is chemically modified to rifampicin and used clinically as an antituberculosis drug, and...
Despite more than two centuries of exploration, including more than six million deep wellbores with depths exceeding 40,000 feet in some parts of the world, our ability to constrain subsurface processes and properties remains limited. Characteristics of the subsurface vary and can be analyzed on a variety of spatial scales....
The function of a protein is defined by its three-dimensional structure, and in understanding the three-dimensional structure of a protein, we gain an understanding of its function and mechanism. Protein structures, especially at high resolution, can provide detailed insights into many elements of enzyme function and catalysis – identifying residues...
Wheat is a globally traded staple crop. Wheat is important in human diets because of its agronomic adaptability, physical characteristics, functionality for the production of leavened products and nutritional value. Two significant characteristics make wheat an important staple food-crop. First, the proteins present in wheat endosperm have attributes that enable...
Mat-forming ectomycorrhizal (EcM) fungi represent a prevalent constituent of many temperate forest ecosystems and create dramatic changes in soil structure and chemistry. EcM mat soil have been shown to have increased microbial respiration rates and have been hypothesized to harbor unique assemblages of fungi and bacteria. The objectives of this...
This dissertation presents results from three studies that address major scientific questions in glacial geology and paleoclimatology for the late Pleistocene and Holocene using relatively new geochemical and statistical techniques. Each of the studies attempts to answer a longstanding question in the respective field using geochemical or statistical methods that...
Precise in situ measurement of the spectral absorption and scattering coefficients in several regions has revealed patterns in the distribution of the inherent optical properties on spatial scales that were previously unobtainable. The precision of the measurements was found to be consistent and unbiased across a variety of oceanic regimes...
The objectives of this thesis were to evaluate the responses of soil microbial communities to physical and chemical disturbances, and associate these responses with soil functional stability and changes in soil quality. The first study consisted of application of heat shocks (HS) to soils with contrasting land use history to...
Three broadly interrelated problems of critical significance to the proper interpretation of melt inclusion (MI) data are addressed in this thesis. The first issue, the petrogenesis of anorthitic plagioclase phenocrysts in MORB lavas, has relevance due to the presence of numerous MI in many high-An feldspars. This problem was addressed...
To protect and restore environmental quality, efficient and effective conservation policies are needed. Designing policies require a sound understanding of the contributions of natural endowments to economic vitality, and the performance and impacts of conservation programs. This dissertation consists of three essays, and addresses several issues relevant to these two...