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Filtering by: Creator Rohlman, Diana Remove constraint Creator: Rohlman, Diana Resource Type Dissertation Remove constraint Resource Type: Dissertation

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  • Investigations of the AhR-induced Treg : transcriptional regulation and suppressive mechanisms

    Creator:
    Rohlman, Diana
    Abstract:
    The aryl hydrocarbon receptor (AhR) has recently been described as a novel therapeutic target, given the potent suppression of multiple immune-mediated diseases following activation by the prototypic ligand, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). In the parent-into-F1 graft-versus-host (GVH) model, suppression of the cytotoxic T-lymphocyte (CTL) response is associated with the presence of CD25⁺CTLA-4⁺IL-10⁺Foxp3[superscript...
    Resource Type:
    Dissertation
    Full Text:
    AN ABSTRACT OF THE DISSERTATION OF Diana Rohlman

  • Exploring Silicone Wristbands as Personal Passive Sampling Devices in a Disaster Scenario

    Creator:
    Samon, Samantha M.
    Abstract:
    Exposure assessment is necessary to determine the frequency and magnitude of environmental contaminants, especially since exposure may lead to adverse health outcomes. Traditional personal exposure assessment tools such as biological samples are limited in their ability to capture a wide range of chemical exposures from a single sample, and others...
    Resource Type:
    Dissertation
    Full Text:
    graduate committee members Dr. Diana Rohlman, Dr. Craig Marcus, Dr. Dave Williams, and Dr. Molly Kile

  • Advanced Approaches in Hazard Assessment of Polycyclic Aromatic Hydrocarbons Using Zebrafish

    Creator:
    Wilson, Lindsay B.
    Abstract:
    The field of toxicology is challenged with a vast number of environmental chemicals and mixtures to which humans and ecosystems are exposed with limited toxicity data available. Chemical hazard assessment traditionally utilizes mammalian models and can be both cost- and time-limiting and may pose ethical concerns. To rapidly tackle this...
    Resource Type:
    Dissertation
    Full Text:
    – Mary Mucia, Cheyenne Pozar, Drs. Susan Tilton, Kim Anderson, Diana Rohlman, Molly Kile, Craig Marcus

  • Applications of Silicone Wristbands to Improve Personal Chemical Exposure Assessment

    Creator:
    Dixon, Holly M.
    Abstract:
    Silicone wristbands are easy-to-wear passive samplers that have been readily adapted into environmental health studies since first reported in 2014. Wristbands can be worn during normal daily activities and sequester a wide range of bioavailable organic chemicals. This dissertation includes a thorough review of silicone wristband technology, as well as...
    Resource Type:
    Dissertation
    Full Text:
    like to thank Dr. Steven O’Connell, Dr. Diana Rohlman, Ricky Scott, Dr. Blair Paulik, Dr. Carey

  • New Configurations of Silicone Passive Sampling Devices: Quantifying Feline and Firefighter Chemical Exposures

    Creator:
    Poutasse, Carolyn M.
    Abstract:
    Silicone wristbands are passive sampling devices (PSD) that sequester bioavailable organic chemicals in the environment. In environmental health studies, silicone wristbands are easy to wear and can provide personal exposure data about complex chemical mixtures. This dissertation includes an overview of PSD technology, a literature review of current wristband research...
    Resource Type:
    Dissertation
    Full Text:
    , Dr. Diana Rohlman, Jessica Scotten, Dr. Lane Tidwell, Dr. Steven O’Connell, Michael Barton, Peter

  • Human Exposure to PAHs in Air, Water, and Crayfish

    Creator:
    Paulik, L. Blair
    Abstract:
    There are many links between exposure to environmental pollution and risks to human health. While advances in the fields of toxicology, exposure science, and environmental chemistry have shown light on many of these links, many more research challenges remain. One major challenge is how to accurately characterize the toxicity of...
    Resource Type:
    Dissertation
    Full Text:
    Jamie for showing me how informative a good thought experiment can be. Thank you to Diana Rohlman

  • New applications and emerging contaminants : developing silicone passive sampling devices for environmental and novel monitoring applications

    Creator:
    O'Connell, Steven G.
    Abstract:
    Passive sampling is a popular technology for environmental monitoring, and silicone is an ideal choice for a variety of passive sampling applications. The silicone work described here encompasses laboratory and field studies that demonstrate the use of this polymer in novel environments, for new applications, and for emerging compounds. Unique...
    Resource Type:
    Dissertation
    Full Text:
    , and surgery of mice, Dr. Diana Rohlman aided in manuscript preparation, study design, autopsy, and

  • Human exposure to polycyclic aromatic hydrocarbons : global cancer risk and metabolism

    Creator:
    Motorykin, Oleksii
    Abstract:
    In recent decades, there has been increased attention on human exposure to, and subsequently toxicity of, Polycyclic Aromatic Hydrocarbons (PAHs). PAHs are widespread organic pollutants and some have been shown to be toxic, carcinogenic and mutagenic. This research was focused on understanding the link between global PAH emissions and lung...
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    Dissertation
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    . Lisandra Santiago-Delgado helped with analysis of urine samples. Dr. Diana Rohlman helped with

  • Investigating the Impact of Temperature and Air Quality on Human Health in At-Risk Populations

    Creator:
    Evoy, Richard E.
    Abstract:
    Climate change is causing people around the world to experience extreme temperature and air pollution events such as wildfires more frequently, and for longer periods of time. Extreme heat events have been widely associated with an increased risk of emergency room visits, occupational heat-related injuries and illnesses, and mortality overall...
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    Dissertation
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    as the graduate committee representative. Dr. Diana Rohlman helped with data collection

  • Implications for Wildfire Health Recommendations and Remediation Strategies: Source, Fate and Risk of PAHs

    Creator:
    Ghetu, Christine, C.
    Abstract:
    (Polycyclic aromatic hydrocarbons) PAHs are widespread in the environment, and are derived from both natural and anthropogenic sources. The physicochemical properties of PAHs along with the wide range of PAH sources leads to their persistence in the environment. Since PAHs are ubiquitous, and have the potential to illicit adverse effects,...
    Resource Type:
    Dissertation
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    . Diana Rohlman for teaching me the importance of science communication, and serving as my graduate