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  • Characterization of the SARS-CoV-2 Nucleocapsid Protein and the Binding to Different Sections of the SARS-CoV-2 Genome

    Creator:
    Pinckney, Seth H.
    Abstract:
    The nucleocapsid protein (N protein) of the severe acute respiratory syndrome coronavirus 2 is known to play an essential part of the virus’ functions. The N protein can protect and package the large 29,903 nucleotide genomic RNA whilst also interacting with structural membrane protein M and the spike protein S....
    Resource Type:
    Honors College Thesis
    Full Text:
    ). Both the CTD and NTD have had their structures solved through X-ray crystallography and/or NMR; the

  • The Crystal Structure of the Potential Drug Target Mycoplasma pneumoniae Glycerol 3-Phosphate Oxidase

    Creator:
    Palioca, Callia K.
    Abstract:
    Mycoplasma pneumoniae is the primary cause of community-acquired pneumonias, including what is commonly known as walking pneumonia. This disease affects people from all demographics, but especially children and older adults. Outbreaks are a significant public health concern and work to develop new pharmacological agents is currently being researched. How M....
    Resource Type:
    Honors College Thesis
    Full Text:
    (GlpO). Using X-ray crystallography, we determined the three-dimensional structure of this enzyme in

  • Peptide Non-planarity Regained

    Creator:
    Biel, Justin T.
    Abstract:
    The planar peptide model has guided our understanding and interpretation of protein crystal structures since its origin in the 1950s. It is well understood that deviations from this model occur, but the majority of peptides are planar, as measured by the standard omega torsion angle. Here, we report the first...
    Resource Type:
    Honors College Thesis
    Full Text:
    influence on non-planarity. Key Words: Non-planarity, X-ray crystallography, Proline, Pyramidalization

  • Liquid-liquid Phase Separation of the Nucleocapsid of SARS-CoV-2

    Creator:
    Hughes, Kaitlyn
    Abstract:
    The nucleocapsid of SARS-CoV-2 is critical for viral genome packaging through binding to viral genomic RNA. Liquid-liquid phase separation, or LLPS, is the formation of microscopic, rapidly reversible, liquid-like immiscible droplets. There is increasing scientific evidence that LLPS underlies the formation of membraneless compartments within cells and that this process...
    Resource Type:
    Honors College Thesis
    Full Text:
    rapid and reversible spatiotemporal compartmentalization of biological constituents and biochemical

  • An Exploration Into The Ever-changing Expanse of Non-periodic Tilings

    Creator:
    Tassin, Ian
    Abstract:
    This paper synthesizes various works Wang tiles up to this point, including: the reduction from the Halting Problem to Wang Tiling Problem and notions around various aspects of periodicity, including minimal period, aperiodicity, and axis-aligned periodicity. Additionally it includes new work, including: a proof that a tiling can be periodic...
    Resource Type:
    Honors College Thesis
    Full Text:
    section 2.2, and the discovery of many aperiodic tilesets, see section 1.1. 1.2 Content Covered in This

  • Characterizing the Interactome of Nitrotyrosine-Calmodulin using Genetic Code Expansion

    Creator:
    Kong, Garth L.
    Abstract:
    A specific tyrosine post-translational modification, called 3-nitro-tyrosine (nitroTyr), has been known to be present on an essential calcium signaling protein called calmodulin (CaM) during oxidative stress. While protein-bound 3-nitro-tyrosine has long been considered a biomarker of OS, it is also hypothesized to be a mechanism for protein signaling. However, purification...
    Resource Type:
    Honors College Thesis
    Full Text:
    Table of Content SECTION I: Background