Index Catalog // ScholarsArchive@OSU

Assessment of roles for the Rho-specific guanine nucleotide dissociation inhibitor (RhoGDI) Ly-GDI in platelet function

Creator:: Thierheimer, Marisa
Abstract:: Platelets undergo morphological changes essential to hemostasis upon activation at sites of vascular injury. The Rho GTPases Rac1, Cdc42, and RhoA drive these changes. Rho guanine nucleotide dissociation inhibitors (RhoGDIs) bind to the Rho GTPases to block the GDP from dissociating from the Rho GTPases, as well as anchoring the...
Resource Type:: Honors College Thesis
Full Text:: the basic region of the GPVI tail. Figure adapted from Watson et al., J Thromb Haemost, 2005; 3:1752

Role of P2Y₁₂ Inhibition in PAR1 Stimulated Platelet Dense Granule Release

Creator:: Laschober, Nicole B.
Abstract:: Platelet activation uses a complex set of pathways to respond to vascular injury during hemostasis. However, thrombosis relies on the same set of pathways. Antiplatelet therapies used to prevent thrombotic events often target the P2Y₁₂ platelet receptor for inhibition but can result in bleeding diathesis or in abnormally high ADP...
Resource Type:: Honors College Thesis
Full Text:: : assessment and quantification," Eur Heart J, vol. 22, no. 17, pp. 1561-71, Sep 2001. [5] R. T. Dorsam and

Janus-Type Wicking Microfluidic Devices for Separation and Collection of Plasma from Blood

Creator:: Unitan, Linus J.
Abstract:: A simple Janus-type membrane-based wicking microfluidic device fabricated on a polycaprolactone-filled glass microfiber membrane enables separation and collection of blood plasma or serum from whole blood. This device bridges the wicking and cut-capillary-based solution transport mechanisms in a single membrane. The initial portion of the device is fabricated using selective...
Resource Type:: Honors College Thesis
Full Text:: of Microfluidic Devices for Blood Plasma Separation—a Designer’s Perspective. J

Quantification of Propofol in Blood Plasma and its Application to Future Clinical Research in Anesthesiology and Perioperative Medicine

Creator:: Bemis, David J.
Abstract:: High Performance Liquid Chromatography-Mass Spectrometry coupled with filtration, centrifugation, and other common sample preparation techniques offers a rapid and robust method for separating and quantifying propofol, a commonly used anesthetic, from human blood and its synthetic analogs. Method development is important for not only optimizing separation and quantification for a...
Resource Type:: Honors College Thesis
Full Text:: Application to Future Clinical Research in Anesthesiology and Perioperative Medicine By David J. Bemis

Winning through Compromise? An Examination of Bipartisanship and Electability

Creator:: Ellingson-Cosenza, Elena J.
Abstract:: In America’s polarized politics, the language that congresspeople use matters. This thesis examines the use of bipartisan communications—in tweets and press releases—of members of the US House of Representatives as an electoral strategy for representatives in districts of varying competitiveness. A linear regression was conducted to analyze the relationship between...
Resource Type:: Honors College Thesis
Full Text:: critical test statistic is 1.96. The absolute value of the t values for blackrep, latinorep, and

Effects of Inhibitors against Syk-BTK-PI3K Signaling on Platelet Function

Creator:: Lofurno, Elizabeth R.
Abstract:: Tyrosine kinases mediate response of blood cells to stimuli and small molecule tyrosine kinase inhibitors (TKIs) serve important roles as drugs in managing hematological diseases. In healthy B cells, the B cell receptor (BCR) activates a tyrosine kinase known as Syk, which then activates BTK, PI3K, PLC􏰃2 and protein kinase...
Resource Type:: Honors College Thesis

Resiliency of United States Power Grids to Inclement Weather Conditions

Creator:: Trevis, Kyle R.
Abstract:: The United States depends on the electrical grid infrastructure for nearly every facet of its operation. Understanding how inclement weather affects the reliability of the grid and what the U.S. is doing to ensure its resiliency will be a key step moving forward into the 21st century as global climate...
Resource Type:: Honors College Thesis
Full Text:: . Wiley Online Library, Douglas, E., McGee, K., McCullough, J. “Texas Leaders Failed to Heed Warnings

Creating and Assessing Cozmo Behaviors for Expressing Emotion

Creator:: Chan, Lilian C.
Abstract:: As human-robot interaction becomes more commonplace, roboticists should understand how robot behaviors are perceived by people to avoid misunderstandings. In our lab, we are exploring the use of a Cozmo as an interactive, break-taking aid in workplace settings. Before our interactive aid can be released into the wild, we must...
Resource Type:: Honors College Thesis
Full Text:: . [5] B. J. Zhang, R. Quick, A. Helmi, and N. T. Fitter, “Socially assistive robots at work: Making

Activation of Co-stimulatory Molecule OX40 Increases Memory T-cell Function and Cytokine Production in Uveitis

Creator:: Hall, Mark
Abstract:: Uveitis is a serious ophthalmological disorder characterized by intraocular infiltration of inflammatory cells. In most cases, uveitis is derived from the adaptive immune response. More specifically, CD4+ T lymphocytes play an important role in the pathogenesis of uveitis by recognizing uveitogenic antigen and orchestrating the immune response. While it is...
Resource Type:: Honors College Thesis
Full Text:: Increases Memory T-cell Function and Cytokine Production in Uveitis Abstract approved

Luteinizing hormone receptor-mediated cell proliferation in canine T-cell lymphoma cells

Creator:: Flint, Camryn
Abstract:: Luteinizing hormone (LH) is secreted in low-amplitude pulses in sexually intact dogs to stimulate synthesis of estrogen and testosterone in females and males, respectively. LH is mainly considered a reproductive hormone, but LH receptors (LHR) have been identified in non-reproductive tissues, including in canine lymphoma and isolated canine T-cell lymphoma...
Resource Type:: Honors College Thesis
Full Text:: proliferation in canine T-cell lymphoma cells by Camryn Flint A THESIS

ScholarsArchive@OSU

Assessment of roles for the Rho-specific guanine nucleotide dissociation inhibitor (RhoGDI) Ly-GDI in platelet function

Role of P2Y₁₂ Inhibition in PAR1 Stimulated Platelet Dense Granule Release

Janus-Type Wicking Microfluidic Devices for Separation and Collection of Plasma from Blood

Quantification of Propofol in Blood Plasma and its Application to Future Clinical Research in Anesthesiology and Perioperative Medicine

Winning through Compromise? An Examination of Bipartisanship and Electability

Effects of Inhibitors against Syk-BTK-PI3K Signaling on Platelet Function

Resiliency of United States Power Grids to Inclement Weather Conditions

Creating and Assessing Cozmo Behaviors for Expressing Emotion

Activation of Co-stimulatory Molecule OX40 Increases Memory T-cell Function and Cytokine Production in Uveitis

Luteinizing hormone receptor-mediated cell proliferation in canine T-cell lymphoma cells

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