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Filtering by: Advisor McClellan, T. J. Resource Type Honors College Thesis

Role of P2Y₁₂ Inhibition in PAR1 Stimulated Platelet Dense Granule Release

Creator:

Laschober, Nicole B.

Abstract:

Platelet activation uses a complex set of pathways to respond to vascular injury during hemostasis. However, thrombosis relies on the same set of pathways. Antiplatelet therapies used to prevent thrombotic events often target the P2Y₁₂ platelet receptor for inhibition but can result in bleeding diathesis or in abnormally high ADP...

Resource Type:

Honors College Thesis

Full Text:

: assessment and quantification," Eur Heart J, vol. 22, no. 17, pp. 1561-71, Sep 2001. [5] R. T. Dorsam and
Assessment of roles for the Rho-specific guanine nucleotide dissociation inhibitor (RhoGDI) Ly-GDI in platelet function

Creator:

Thierheimer, Marisa

Abstract:

Platelets undergo morphological changes essential to hemostasis upon activation at sites of vascular injury. The Rho GTPases Rac1, Cdc42, and RhoA drive these changes. Rho guanine nucleotide dissociation inhibitors (RhoGDIs) bind to the Rho GTPases to block the GDP from dissociating from the Rho GTPases, as well as anchoring the...

Resource Type:

Honors College Thesis

Full Text:

the basic region of the GPVI tail. Figure adapted from Watson et al., J Thromb Haemost, 2005; 3:1752