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Filtering by: Advisor Smith, Jane E. Remove constraint Advisor: Smith, Jane E. Resource Type Honors College Thesis Remove constraint Resource Type: Honors College Thesis

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  • Identification of a Bioactive Aryl Ether from a South African Tunicate

    Creator:
    White, Cora L.
    Abstract:
    Chemical compounds produced by organisms, or natural products, are excellent sources of inspiration for anticancer pharmaceutical discovery (Rodrigues et al., 2016). Microtubule targeting agents are a specific class of compounds, often discovered from natural sources, that have been developed as clinically successful anticancer therapies (Steinmetz and Prota, 2018). In the...
    Resource Type:
    Honors College Thesis
    Full Text:
    : __________________________________________________________________ Jane E. Ishmael, Ph.D. Chemical compounds produced by organisms, or natural products, are

  • Investigation of autophagy-assisted cell death in response to the cancer cell toxin coibamide A

    Creator:
    Tan, Michelle
    Abstract:
    Autophagy, a homeostatic degradation pathway, has a role in promoting cell survival under stress conditions, but can also promote cell death under conditions of sustained stress. This project investigates the cytotoxic potential of coibamide A and other natural products in autophagy-deficient and wild-type mouse embryonic fibroblasts (MEFs). Wild-type MEFs were...
    Resource Type:
    Honors College Thesis
    Full Text:
    : ______________________________________________________ Jane Ishmael Autophagy, a homeostatic degradation pathway, has a role in promoting cell