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  • Synthesis and anticoagulant function of heparin containing block copolymers on polystyrene microspheres

    Creator:
    Fry, Allyson Kaye
    Abstract:
    Contact of blood with the surfaces of synthetic materials is associated with spontaneous protein adsorption, initiating platelet aggregation, the coagulation cascade, and the eventual development of a stable clot. Current therapy to inhibit implant-induced thrombosis is life-long administration of systemic anticoagulants. An alternative to the systemic administration of anticoagulant drugs...
    Resource Type:
    Masters Thesis
    Full Text:
    synthetic material surfaces is associated with spontaneous protein adsorption, initiating platelet

  • Nisin adsorption to PEO-PPO-PEO tri-block copolymer layers and its resistance to elution by fibrinogen

    Creator:
    Ryder, Matthew P.
    Abstract:
    While hydrophobic surfaces coated with the poly[ethylene oxide]-poly[propylene oxide]-poly[ethylene oxide] (PEO-PPO-PEO) surfactant Pluronic® F108 are highly resistant to plasma protein adsorption, the antimicrobial peptide nisin has been observed to adsorb in multilayer quantities at such surfaces, and the PEO chains themselves suggested to inhibit nisin exchange by blood proteins. But...
    Resource Type:
    Masters Thesis
    Full Text:
    exists an abundance of literature describing the nonfouling mechanisms of material surfaces with