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Filtering by: Advisor Ayres, James W. Remove constraint Advisor: Ayres, James W. Resource Type Masters Thesis Remove constraint Resource Type: Masters Thesis

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  • Absorption of benzocaine -³H from semi-solid dosage forms following rectal administration in rats

    Creator:
    Lorskulsint, Duangchit
    Abstract:
    The effect of concentration, vehicle and surfactant on the absorption of benzocaine -³H across the rat's rectal mucosa was investigated. Blood radioactivity levels were determined after the application of benzociane -³H containing suppositories and ointments. A wet oxidation method was used for sample digestion. Since the radioactivity counted is the...
    Resource Type:
    Masters Thesis
    Full Text:
    Duangchit Lorskulsint ACKNOWLEDGMENT I would like to express my deepest gratitude to Dr. J. W. Ayres for

  • Bioavailability and pharmacokinetics of dyphylline and theophylline in rabbits

    Creator:
    Mayo, Charles Edward
    Abstract:
    The bioavailability and pharmacokinetics of theophylline in rabbits were determined following both oral and intravenous administration of the drug. Serum theophylline concentrations were determined using high pressure liquid chromatography. Pharmacokinetic parameters were determined and verified by computer analysis. The overall mean Beta disposition constant was 0.089 hr⁻¹ which corresponds to...
    Resource Type:
    Masters Thesis
    Full Text:
    DYPHYLLINE AND THEOPHYLLINE IN RABBITS Abstract approved: Redacted for Privacy Dr. James W. Ayres V Part

  • Comparative pharmacokinetic studies of dyphylline and some dyphylline prodrugs

    Creator:
    Huang, Hua-pin
    Abstract:
    Dyphylline is an analog of theophylline and the latter is the most popular member of the methylxanthine family in use for the treatment of asthma. Although dyphylline is devoid of some problems associated with theophylline, a reported short half-life has made it's clinical usefulness limited. To avoid this problem a...
    Resource Type:
    Masters Thesis
    Full Text:
    ....- v,....- ,-...- Dr. James W. Ayre i Dyphylline is an analog of theophylline and the latter is the

  • Assay and pharmacokinetics of dyphylline following oral administration in humans

    Creator:
    Gisclon, Lee Gehl
    Abstract:
    Improved assay methods for determination of dyphylline levels in plasma, saliva, and urine utilizing high pressure liquid chromatography have been developed. Detection of levels as low as 25 ng/ml from 0.5 ml plasma and 50 ng/ml from 0.5 ml saliva were possible. Both procedures utilized the same extraction process. A...
    Resource Type:
    Masters Thesis
    Full Text:
    ORAL ADMINISTRATION IN HUMANS Abstract approved: Redacted for privacy James W. Ayr4s(e7.D. Improved

  • Chelating agents in the drug dosage design of iron preparations

    Creator:
    Ghannam, Musa
    Abstract:
    The role of iron in the body is well known for it is a component of hemoglobin, myoglobin, cytochrome, enzyme catalase and peroxidase. Iron deficiency anemia is widespread among vulnerable groups in industrialized societies and in the general population of tropical developing areas. In the United States there are ten...
    Resource Type:
    Masters Thesis
    Full Text:
    ACKNOWLEDGMENTS I would like to express my deepest appreciation to Dr. J. W. Ayres who was an excellent advisor

  • Pharmacokinetic investigation of a potential drug interaction : aminophylline and prednisone

    Creator:
    Anderson, John L.
    Resource Type:
    Masters Thesis
    Full Text:
    Potential Drug Interaction: Aminophylline and Prednisone Abstract approved: Redacted for Privacy es W

  • The absolute bioavailability of dyphylline tablets in human subjects

    Creator:
    Huston, Thomas K.
    Abstract:
    Dyphylline has been shown to be rapidly and completely absorbed from oral tablets in an absolute bioavailability study. In a pilot study two healthy male subjects received 1000 mg of dyphylline via intravenous infuson at a rate of 50 mg/min (1.0 ml/min) for 20 minutes. Plasma samples were collected for...
    Resource Type:
    Masters Thesis
    Full Text:
    Abstract approved: Redacted for Privacy 0 James W. Ayres,(PV.D. Dyphylline has been shown to be rapidly

  • Antimicrobial vaginal dosage forms employing Dimethyl Fumarate or propionic acid

    Creator:
    Sahajwalla, Chandrahas G.
    Abstract:
    Propionic acid, live Propionibacterium shermanii, and Dimethyl Fumarate (DMF) were tested for their stimulatory or inhibitory efects on yeast, bacteria, and molds. The amount of propionic acid required for inhibition of molds was strain specific and equal to or less than that required for inhibition of the yeasts. Live P....
    Resource Type:
    Masters Thesis

  • Pharmacokinetics of theophylline and it's N-7 derivatives in rabbits

    Creator:
    Tavipatana, Wattanaporn
    Abstract:
    Pharmacokinetics of theophylline and N-7 substituted theophylline in rabbits when administered alone and in various combinations were investigated. This thesis has four chapters dealing with etophylline and theophylline; proxyphylline and theophylline; dyphylline and theophylline; and etophylline, proxyphylline and dyphylline pharmacokinetics when administered concomitantly. All chapters are interrelated. Each chapter has...
    Resource Type:
    Masters Thesis
    Full Text:
    Tavipatana ACKNOWLEDGEMENTS I would like to thank my advisor, Dr. J. W. Ayres for his friendliness

  • Preformulation studies for oral dosage forms of lactobacilli

    Creator:
    Liou, Grace Yow-Hwa
    Abstract:
    Lactobacilli have been used in the dairy and pharmaceutical industries because of their nutritious and/or therapeutic effects. Lactobacillus acidophilus and Lactobacillus bulqaricus were isolated from a commercially available product and studied for their growth and colony characteristics as described in Chapter I and Chapter II. Survival of these lactobacilli in...
    Resource Type:
    Masters Thesis
    Full Text:
    Abstract approved: Redacted for Privacy )N Dr. James W. Oers ABSTRACT Lactobacilli have been used in the