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  • Thesis2.doc

    Creator:
    Lo, Pachida C.
    Abstract:
    We are developing a flavin-containing (Fmo) knock-out mouse for Fmo2 that will be utilized to elucidate the role of active human FMO isoform 2 (FMO2.1) in xenobiotic metabolism and toxicity. Since FMO2 is primarily expressed in lung this will provide information on how 27% of African-Americans and 5% of Hispanics...
    Full Text:
    incorporate FAD and is not detected on western blots of human pulmonary microsomes presumably due to

  • Thesis1.doc

    Creator:
    Lo, Pachida C.
    Abstract:
    We are developing a flavin-containing (Fmo) knock-out mouse for Fmo2 that will be utilized to elucidate the role of active human FMO isoform 2 (FMO2.1) in xenobiotic metabolism and toxicity. Since FMO2 is primarily expressed in lung this will provide information on how 27% of African-Americans and 5% of Hispanics...
    Full Text:
    environmental pulmonary toxicants. Researchers recently reported finding high levels of Fmo1, and low levels of