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Alkylation studies on Hagemann's ester: an approach to the synthesis of the trisporic acids

Creator:

Sung, Wing Lam

Abstract:

Sequential alkylation of Hagemann's ester with methyl and methallyl halides has been studied. Treatment of Hagemann's ester with methyl iodide and sodium ethoxide gave a mixture of 21 and 25 in a ratio of 4:1. Alkylation of 21 with methallyl chloride and potassium t-butoxide afforded a mixture of 37 and...

Resource Type:

Masters Thesis

Full Text:

Alkylation studies on Hagemann's ester : an approach to the
The mechanism of the Hofmann-Martius rearrangement of N-alkylaniline

Creator:

Klein, George William

Resource Type:

Masters Thesis

Full Text:

observation of the lack of multiple ring alkylation in a typical rearrangement of this type was cited as
Alkylation of peptides and proteins by S-(2-chloroethyl)glutathione and characterization of adducts by mass spectrometry

Creator:

Erve, John C. L.

Abstract:

Glutathione, a ubiquitous intracellular tripeptide, protects cells by reacting with electrophiles and radicals that can damage cellular macromolecules. However, glutathione conjugation is now recognized as one mechanism by which drugs and xenobiotics can also be converted to reactive intermediates having toxic consequences to cells. The halogenated alkane 1,2-dichloroethane forms S-(2-chloroethyl)...

Resource Type:

Dissertation

Full Text:

degree of Doctor of Philosophy in Toxicology presented on April 26, 1995. Title: Alkylation of Peptides