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  • Development and in vivo testing of a gastric retention device (GRD) in dogs

    Creator:
    Kapsi, Shivakumar G.
    Abstract:
    This thesis describes 1) development of a gastric retention device (GRD) to increase gastric retention time of certain drugs, 2) product formulations of an immediate release itraconazole and controlled-release ketoprofen. GRD was fabricated from crosslinked carbohydrate polymers. Rate and extent of hydration of the film in water and in simulated...
    Resource Type:
    Dissertation
    Full Text:
    every formulation and delivery system developed is intended to deliver a particular drug in a

  • In vitro and in vivo testing of a gastric retention device : development and evaluation of a new colonic delivery system

    Creator:
    Ahmed, Iman Saad
    Abstract:
    This thesis describes evaluation of a gastric retention device (GRD) developed at Oregon State University. The device was originally fabricated from Xanthan gum and Locust bean gum. A modified gastric retention device containing other additives was developed and investigated in this work. The modified device was evaluated in vitro for...
    Resource Type:
    Dissertation
    Full Text:
    a New Colonic Delivery System. INTRODUCTION Site-specific drug targeting to different regions in

  • The study of valproate sodium formulations in vitro

    Creator:
    Sartnurak, Soisurin
    Abstract:
    The stability of valproate sodium syrup repackaged in three types of unit dose containers was studied. Two-milliliter samples of commercial valproate sodium syrup 250 mg/5 ml (of valproic acid) were packaged in polypropylene oral syringes, glass oral syringes, and glass vials (126 of each type). These were stored at 4,...
    Resource Type:
    Masters Thesis
    Full Text:
    lower tempera- tures. An average of 86% of the drug lost from the polypropylene syringes was recovered