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  • Andrew Osborn Seminar.pdf

    Creator:
    Osborn, Andrew
    Abstract:
    Pactamycin, a complex aminocyclitol compound produced by Streptomyces pactum, has significant antibiotic, antitumor, and antiplasmodial activity. However, this natural product has not been developed for clinical use due to its high cytotoxicity. Modulation of its biological properties by chemical synthesis has been difficult due to its complex chemical structure. Therefore,...
    Full Text:
    Research Thesis Seminar Presentation Streptomyces pactum produces the antitumor antibiotic pactamycin

  • Andrew Osborn Thesis.pdf

    Creator:
    Osborn, Andrew
    Abstract:
    Pactamycin, a complex aminocyclitol compound produced by Streptomyces pactum, has significant antibiotic, antitumor, and antiplasmodial activity. However, this natural product has not been developed for clinical use due to its high cytotoxicity. Modulation of its biological properties by chemical synthesis has been difficult due to its complex chemical structure. Therefore,...
    Full Text:
    Abstract Pactamycin, a complex aminocyclitol compound produced by Streptomyces pactum, has significant