Throughput-oriented processors, such as graphics processing units (GPUs), have been increasingly used to accelerate general purpose computing, including machine learning models that are being utilized in numerous disciplines. Thousands of concurrently running threads in a GPU demand a highly efficient memory subsystem for data supply in GPUs. In this dissertation,...
RNA-Sequencing (RNA-Seq) has rapidly become the de facto technique in transcriptome studies. However, established statistical methods for analyzing experimental and observational microarray studies need to be revised or completely re-invented to accommodate RNA-Seq data's unique characteristics. In this dissertation, we focus on statistical analyses performed at two particular stages in...
Antisense oligonucleotide (AO)-mediated exon-skipping therapeutics shows great promise in correcting frame-disrupting mutations in the DMD gene for Duchenne muscular dystrophy. However, insufficient systemic delivery limits clinical adoption. Previously, we showed that a glucose/fructose mixture augmented AO delivery to muscle in mdx mice. Here, we evaluated if fructose alone could enhance...
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Manner in mdx Mice
Limin Cao1,2, Gang Han1, Caorui Lin1, Ben Gu1, Xianjun Gao1, Hong M Moulton3, Yiqi
Antisense oligonucleotide (AO)-mediated exon-skipping therapeutics shows great promise in correcting frame-disrupting mutations in the DMD gene for Duchenne muscular dystrophy. However, insufficient systemic delivery limits clinical adoption. Previously, we showed that a glucose/fructose mixture augmented AO delivery to muscle in mdx mice. Here, we evaluated if fructose alone could enhance...
Antisense oligonucleotide (AO)-mediated exon-skipping therapeutics shows great promise in correcting frame-disrupting mutations in the DMD gene for Duchenne muscular dystrophy. However, insufficient systemic delivery limits clinical adoption. Previously, we showed that a glucose/fructose mixture augmented AO delivery to muscle in mdx mice. Here, we evaluated if fructose alone could enhance...
Diatomaceous soils are a geological material whose engineering properties do not readily conform to the widely accepted and used mechanical and behavioral frameworks. This ambiguity results in design difficulties and geotechnical failures which can be costly. Diatomaceous soils have diatoms in their matrix. Diatoms are unicellular algae with an inert...
In a wireless sensor network, sensor nodes are deployed in an ad hoc fashion and they deliver data packets using multihop transmission. However, transmission failures occur frequently in the multihop transmission over wireless media. Thus, a loss recovery mechanism is required to provide end-to-end reliability. In addition, because the sensor...
Various natural language processing (NLP) tasks necessitate deep models that are fast, efficient, and small based on their ultimate application at the edge or elsewhere. While significant investigation has furthered the efficiency and reduced the size of these models, reducing their downstream latency without significant trade-offs remains a difficult task....
This work presents a new energy saving technique for modern digital designs. We propose Time Interleaved Multi-Rail (TIMR) - a method for providing two dynamic supply rails to a circuit. This technique uses the first supply rail to mask the transition delay while changing the voltage of the second rail....
A distributed system is a network of multiple autonomous computational nodes designed primarily for performance scalability and robustness. The performance of a distributed system depends critically on how tasks and resources are distributed among the nodes. Thus, a main thrust in distributed system research is to design schemes for distributing...